Publications

For a free electronic reprint of any Burke Group publication, please email Ramona Rudzinski at ramonar@illinois.edu

123. Amphotericin B Derivatives with Improved Therapeutic Index Martin D. Burke, Stephen A. Davis, Brice E. Uno, Justin Struble, Ian Dailey US Patent 11,970,512. 2024

122. Molecule Maker Lab Institute: Accelerating, advancing, and democratizing molecular innovation Burke, M.D.; Denmark, S.E.; Diao, Y.; Han, J.; Switzky, R.; Zhao, H. AI Mag. 2024, DOI: 10.1002/aaai.12154

121. Saliva-based Molecular Testing for SARS-COV-2 Martin D. Burke, Timothy M. Fan, Paul J. Hergenrother, Christopher Byron Brooke, Diana Rose E. Ranoa, Robin L. Holland, Fadi G. Alnaji, Kelsie J. Green, Leyi Wang, US Patent 11,926,877. 2024

120. Delocalized, Asynchronous, Closed-Loop Discovery of Organic Laser Emitters, Strieth-Kalthoff, F.; Hao, H.; … Adachi, C.; Grzybowski, B.A.; Cronin, L.; Hein, J.E.; Burke. M.D.; Aspuru-Guzik, A. Science 2024 DOI: 10.1126/science.adk9227

119. Closed-Loop Transfer Enables AI to Yield Chemical Knowledge Angello, N.H.; Friday, D.M.; Hwang, C.; Yi, S.; … Aspuru-Guzik, A.; Burke, M.D.; Schroeder, C.M.; Diao, Y.; Jackson, N.E. ChemRxiv 2023, DOI: 10.26434/chemrxiv-2023-jqbqt

118. Rapid Automated Iterative Small Molecule Synthesis Wang, W.; Angello, N.H.; Blair, D.J.; Medine, K.N.S.; Tyrikos-Ergas, T.; LaPorte, A.J.; Burke, M. D. ChemRxiv 2023, DOI: 10.26434/chemrxiv-2023-qpf2x

117. Tuning sterol extraction kinetics yields a renal-sparing polyene antifungal, Arun Maji, Corinne P. Soutar, Jiabao Zhang, Agnieszka Lewandowska, Brice E. Uno, Su Yan, Yogesh Shelke, Ganesh Murhade, Evgeny Nimerovsky, Collin G. Borcik, Andres S. Arango, Justin D. Lange, Jonnathan P. Marin-Toledo, Yinghuan Lyu, Keith L. Bailey, Patrick J. Roady, Jordan T. Holler, Anuj Khandelwal, Anna M. SantaMaria, Hiram Sanchez, Praveen R. Juvvadi, Gina Johns, Michael J. Hageman, Joanna Krise, Teclegiorgis Gebremariam, Eman G. Youssef, Ken Bartizal, Kieren A. Marr, William J. Steinbach, Ashraf S. Ibrahim, Thomas F. Patterson, Nathan P. Wiederhold, David R. Andes, Taras V. Pogorelov, Charles D. Schwieters, Timothy M. Fan, Chad M. Rienstra, Martin D. Burke, Nature, 2023, DOI: 10.1038/s41586-023-06710-4.

116. Computational prediction of complex cationic rearrangement outcomes, Klucznik, T.; Syntrivanis, L.; Baś, S.; Mikulak-Klucznik, B.; Moskal, M.; Szymkuć, S.; Mlynarski, J.; Gadina, L.; Beker, W.; Burke, M.D.; Tiefenbacher, K.; Grzybowski, B.A. Nature 2023 DOI: 10.1038/s41586-023-06854-3

115. Minimizing higher-order aggregation maximizes iron mobilization by small molecules, Andrew D. Blake, Jianhua Chao, Anna M. SantaMaria, Stella Ekaputri, Kelsie J. Green, Samantha T. Brown, Christopher K. Rakowski, Eun-Kyung Choi, Luisa Aring, Peng-Jui Chen, Nicholas M. Snead, Douglas M. Matje, Tao Geng, Angela Octaviani, Keith Bailey, Stanley J. Hollenbach, Timothy M. Fan, Young-Ah Seo, Martin D. Burke, Nature Chem. Bio., 2024, DOI: 10.1038/s41589-024-01596-3

114. MIDA- and TIDA-Boronates Stabilize α-Radicals Through B−N Hyperconjugation, Antonio J. Laporte, Jack E. Feldner, Jan C. Spies, Tom J. Maher, Martin D. Burke, Angew. Chem. Int. Ed. Engl. 2023, DOI: 10.1002/anie.202309566

113. Segmental Dynamics of Membranous Cholesterol are Coupled, Lisa A. Della Ripa, Joseph M. Courtney, Samantha M. Phinney, Collin G. Borcik, Martin D. Burke, Chad M. Rienstra, and Taras V. Pogorelov, 2023, J. Am. Chem. Soc. 145 (28), 15043-15048. DOI: 10.1021/jacs.3c01775

112. SynerGPT: In-Context Learning for Personalized Drug Synergy Prediction and Drug Design, Carl Edwards, Aakanksha Nai, Tushar Khot, Martin D. Burke, Heng Ji, Tom Hope, 2023, bioRxiv, doi: https://doi.org/10.1101/2023.07.06.54775

111. Property-Guided Generative Modelling for Robust Model-Based Design with Imbalanced Data, Saba Ghaffari, Ehsan Saleh, Alexander G. Schwing, Yu-Xiong Wang, Martin D. Burke, & Saurabh Sinha, 2023, arXiv preprint arXiv:2305.13650.

110. Small Molecule-Mediated Restoration of Airway Surface Physiology in Human Cystic Fibrosis Lung Epithelia Martin D. Burke, Katrina A. (Diaz) Muraglia, Mark Shtilerman, US Patent 11,850,256. 2023

  • See also: AU Patent 2017248394 2023, JP Patent 7041961 2022

109. Genotype-agnostic Rescue of Cystic Fibrosis with Small Molecule Bicarbonate Channels Martin D. Burke, Michael Welsh, Rajeev S. Chorghade, Katrina A. (Diaz) Muraglia, JP Patent 7355335. 2023

108. Closed-loop optimization of general reaction conditions for heteroaryl Suzuki-Miyaura coupling, Nicholas H. Angello, Vandana Rathore, Wiktor Beker, Agnieszka Wołos, Edward R. Jira, Rafał Roszak, Tony C. Wu, Charles M. Schroeder, Alán Aspuru-Guzik, Bartosz A. Grzybowski, Martin D. Burke, Science, 2022, 378, 399-405. DOI: https://doi.org/10.1021/acscatal.2c03245

107. Stereospecific Csp3 Suzuki-Miyaura Cross-Coupling That Evades b-Oxygen Elimination, Antonio J. LaPorte, Yao Shi, Jason E. Hein, and Martin D. Burke, ACS Catal. 2022, 12, 10905-10912

106. A rationally designed molecular prosthetic for cystic fibrosis, A Lewandowska, I Thornell, C Soutar, K Green, J Lange, D Miller, T Tarara, T Pogorelov, C Rienstra, M Welsh, J Weers, M Burke, J. Cystic Fibrosis 2022, 21, S337.

105. A dry powder aerosol comprising a small molecule prosthetic ion-channel for treatment of people with cystic fibrosis, D Miller, T Tarara, S Lyons, M Burke, A Lewandowska, C Soutar, J Weers, J. Cystic Fibrosis 2022, 21, S229.

104. A small molecule redistributes iron in ferroportin-deficient mice and patient-derived primary macrophages, Stella Ekaputria, Eun-Kyung Choi, Manuela Sabelli, Luisa Aring, Kelsie J. Green, JuOae Chang, Kai Bao, Hak Soo Choi, Shigeki Iwase, Jonghan Kim, Elena Corradini, Antonello Pietrangelo, Martin D. Burke and Young Ah Seo Proc. Natl. Acad. Sci. U.S.A. 2022, 119, e2121400119 https://doi.org/10.1073/pnas.2121400119

103. Targeting fungal membrane homeostasis with imidazopyrazoindoles impairs azole resistance and biofilm formation, Nicole M. Revie, Kali R. Iyer, Michelle E. Maxson, Jiabao Zhang, Su Yan, Caroline M. Fernandes, Kirsten J. Meyer, Xuefei Chen, Iwona Skulska, Meea Fogal, Hiram Sanchez, Saif Hossain, Sheena Li, Yoko Yashiroda, Hiroyuki Hirano, Minoru Yoshida, Hiroyuki Osada, Charles Boone, Rebecca S. Shapiro, David R. Andes, Gerard D. Wright, Justin R. Nodwell, Maurizio Del Poeta, Martin D. Burke, Luke Whitesell, Nicole Robbins & Leah E. Cowen Nature Commun 2022, 13, 3634, https://doi.org/10.1038/s41467-022-31308-1

102. MIDA Anhydride and Reaction with Boronic Acids, Aidan M. Kelly, Peng-Jui Chen, Jenna Klubnick, Daniel J. Blair, and Martin D. Burke Org. Synth. 2022, 99, 92 DOI: 10.15227/orgsyn.099.0092

101. Digitizing Chemical Synthesis in 3D Printed Reactionware, Andrius Bubliauskas, Daniel J. Blair, Henry Powell-Davies, Philip J. Kitson, Martin D. Burke, Leroy Cronin, Angew. Chem. Int. Ed. 2022, e202116108; Angew. Chem. 2022, e202116108

100. Mitigation of SARS-CoV-2 Transmission at a Large Public University, Diana Rose E. Ranoa, Robin L. Holland, Fadi G. Alnaji, Kelsie J. Green, Leyi Wang, Richard L. Fredrickson, Tong Wang, George N. Wong, Johnny Uelmen, Sergei Maslov, Ahmed Elbanna, Zachary J. Weiner, Alexei V. Tkachenko, Hantao Zhang, Zhiru Liu, Sanjay J. Patel, John M. Paul, Nickolas P. Vance, Joseph G. Gulick, Sandeep Puthanveetil Satheesan, Isaac J. Galvan, Andrew Miller, Joseph Grohens, Todd J. Nelson, Mary P. Stevens, P. Mark Hennessy, Robert C. Parker Jr, Edward Santos, Charles Brackett, Julie D. Steinman, Melvin R. Fenner Jr, Kirstin Dohrer, Kraig Wagenecht, Michael DeLorenzo, Laura Wilhelm-Barr, Brian R. Brauer, Catherine Best-Popescu, Gary Durack, Nathan Wetter, David M. Kranz, Jessica Breitbarth, Charlie Simpson, Julie A. Pryde, Robin N. Kaler, Chris Harris, Allison C. Vance, Jodi L. Silotto, Mark Johnson, Enrique Valera, Patricia K. Anton, Lowa Mwilambwe, Stephen P. Bryan, Deborah S. Stone, Danita B. Young, Wanda E. Ward, John Lantz, John A. Vozenilek, Rashid Bashir, Jeffrey S. Moore, Mayank Garg, Julian C. Cooper, Gillian Snyder, Michelle H. Lore, Dustin L. Yocum, Neal J. Cohen, Jan E. Novakofski, Melanie J. Loots, Randy L. Ballard, Mark Band, Kayla M. Banks, Joseph D. Barnes, Iuliana Bentea, Jessica Black, Jeremy Busch, Hannah Christensen, Abigail Conte, Madison Conte, Michael Curry, Jennifer Eardley, April Edwards, Therese Eggett, Judes Fleurimont, Delaney Foster, Bruce W. Fouke, Nicholas Gallagher, Nicole Gastala, Scott A. Genung, Declan Glueck, Brittani Gray, Andrew Greta, Robert M. Healy, Ashley Hetrick, Arianna A Holterman, Nahed Ismail, Ian Jasenof, Patrick Kelly, Aaron Kielbasa, Teresa Kiesel, Lorenzo M. Kindle, Rhonda L. Lipking, Yukari C. Manabe, Jade Mayes, Reubin McGuffin, Kenton G. McHenry, Agha Mirza, Jada Moseley, Heba H. Mostafa, Melody Mumford, Kathleen Munoz, Arika D. Murray, Moira Nolan, Nil A. Parikh, Andrew Pekosz, Janna Pflugmacher, Janise M. Phillips, Collin Pitts, Mark C. Potter, James Quisenberry, Janelle Rear, Matthew L. Robinson, Edith Rosillo, Leslie N. Rye, MaryEllen Sherwood, Anna Simon, Jamie M. Singson, Carly Skadden, Tina H. Skelton, Charlie Smith, Mary Stech, Ryan Thomas, Matthew A. Tomaszewski, Erika A. Tyburski, Scott Vanwingerden, Evette Vlach, Ronald S. Watkins, Karriem Watson, Karen C. White, Timothy L. Killeen, Robert J. Jones, Andreas C. Cangellaris, Susan A. Martinis, Awais Vaid, Christopher B. Brooke, Joseph T. Walsh, William C. Sullivan, Rebecca L. Smith, Nigel D. Goldenfeld, Timothy M. Fan, Paul J. Hergenrother, Martin D. Burke Nature Commun 2022, 13, 3207. https://doi.org/10.1038/s41467-022-30833-3

99. Using automated synthesis to understand the role of side chains on molecular charge transport, Songsong Li, Edward R. Jira, Nicholas H. Angello, Jialing Li, Hao Yu, Jeffrey S. Moore, Ying Diao, Martin D. Burke, and Charles M. Schroeder Nature Commun 2022, 13, 2102. https://doi.org/10.1038/s41467-022-29796-2

98. Automated iterative Csp3-C bond formation, Daniel J. Blair, Sriyankari Chitti, Melanie Trobe, David M. Kostyra, Hannah M. S. Haley, Richard L. Hansen, Steve G. Ballmer, Toby J. Woods, Wesley Wang, Vikram Mubayi, Michael J. Schmidt, Robert W. Pipal, Greg. F. Morehouse, Andrea M. E. Palazzolo Ray, Danielle L. Gray, Adrian L. Gill & Martin D. Burke Nature 2022, 604, 92-97. https://doi.org/10.1038/s41586-022-04491-w

97. A Materials Acceleration Platform for Organic Laser Discovery, Tony C. Wu, Andrés Aguilar Granda, Kazuhiro Hotta, Sahar Alasvand Yazdani, Robert Pollice, Jenya Vestfrid, Han Hao, Cyrille Lavigne, Martin Seifrid, Nicholas H. Angello, Fatima Bencheikh, Jason E. Hein, Martin D. Burke, Chihaya Adachi, Alán Aspuru-Guzik Advanced Materials, 2022, in press; ChemRxiv. Cambridge: Cambridge Open Engage; 2022 DOI 10.26434/chemrxiv-2022-9zm65

96. Automated Synthesis for Single-Molecule Electronics, Edward R. Jira, Songsong Li, Nicholas H. Angello, Jialing Li, Jeffrey S. Moore, Martin D. Burke, Charles M. Schroeder Bulletin of the American Physical Society, 2022

95. Machine Learning May Sometimes Simply Capture Literature Popularity Trends: A Case Study of Heterocyclic Suzuki-Miyaura Coupling, Wiktor Beker, Rafał Roszak, Agnieszka Wołos, Nicholas H. Angello, Vandana Rathore, Martin D. Burke, and Bartosz A. Grzybowski J. Am. Chem. Soc. 2022, 144, 11, 4819–4827 https://doi.org/10.1021/jacs.1c12005

94. Iterations from the chemical cosmos, Danielle C. Loving and Martin D. Burke Nature Synth 1, 11–12 2022, https://doi.org/10.1038/s44160-021-00014-z

93. Saliva-based Molecular Testing for SARS-COV-2 Martin
D. Burke, Timothy M. Fan, Paul J. Hergenrother, Christopher Byron Brooke, Diana Rose E. Ranoa, Robin L. Holland, Fadi G. Alnaji, Kelsie J. Green, Leyi Wang, US Patent 11,530,457. 2022

92. Restoring Physiology in Iron-Deficient Organisms using Small Molecules Martin D. Burke, Anthony S. Grillo, US Patent 11,517,540. 2022

  • See also: AU Patent 2016205030, 2020
  • See also: EPO/DE/FR/GB Patent 3242723, 2021
  • See also: JP Patent 6725515, 2020

91. Validation of a molecular assay to detect SARS-CoV-2 in saliva, Janet L. Pitman, Arthur J. Morris, Stephen Grice, Joseph T. Walsh, Leyi Wang, Martin D. Burke, Amanda Dixon-McIver The New Zealand Medical Journal, 2021, 134, 1547.

90. Chemical-reaction-aware molecule representation learning, Hongwei Wang, Weijiang Li, Xiaomeng Jin, Kyunghyun Cho, Heng Ji, Jiawei Han, Martin D. Burke arXiv 2021; https://arxiv.org/abs/2109.09888

89. Fungicidal Amphotericin B Sponges are Assemblies of Staggered Asymmetric Homodimers Encasing Large Void Volumes, Agnieszka Lewandowska, Corinne P. Soutar, Alexander I. Greenwood, Evgeny Nimerovsky, Ashley M. De Lio, Jordan T. Holler, Grant S. Hisao, Anuj Khandelwal, Jiabao Zhang, Anna M. SantaMaria, Charles D. Schwieters, Taras V. Pogorelov, Martin D. Burke & Chad M. Rienstra Nature Structural & Molecular Biology 2021, 12, 972-981 DOI: 10.1038/s41594-021-00685-4

88. Transition between Nonresonant and Resonant Charge Transport in Molecular Junctions, Songsong Li, Hao Yu, Jialing Li, Nicholas Angello, Edward R. Jira, Bo Li, Martin D. Burke, Jeffrey S. Moore, and Charles M. Schroeder Nano Letters 2021, 21 (19), 8340-8347 DOI: 10.1021/acs.nanolett.1c02915

87. Well-Tolerated Amphotericin B Derivatives That Effectively Treat Visceral Leishmaniasis, Christelle Morelle, Angana Mukherjee, Jiabao Zhang, Fereshteh Fani, Anuj Khandelwal, Hélène Gingras, Jocelyn Trottier, Olivier Barbier, Philippe Leprohon, Martin D. Burke, and Marc Ouellette ACS Infectious Diseases 2021, 7 (8), 2472-2482 DOI: 10.1021/acsinfecdis.1c00245

86. Sterol Sponge Mechanism Is Conserved for Glycosylated Polyene Macrolides, Xiaorui Guo, Jiabao Zhang, Xinyi Li, Emily Xiao, Justin D. Lange, Chad M. Rienstra, Martin D. Burke, and Douglas A. Mitchell ACS Central Science 2021 7 (5), 781-791 DOI: 10.1021/acscentsci.1c00148

85. Hybrid Amphotericin B Derivatives with Reduced Toxicity Martin D. Burke, Anuj Khandelwal (deceased), Jiabao Zhang, Anna SantaMaria, US Patent 11,198,705. 2021

84. Amphotericin B Derivatives with Improved Therapeutic Index Justin Struble, Martin D. Burke, Ian Dailey, Nagarjuna Palyam, David M. Knapp, Pulin Wang, Stephen A. Davis, Brice E. Uno, Kaitlyn C. Gray, US Patent 11,117,920. 2021

83. Amphotericin B Derivatives with Improved Therapeutic Index Justin Struble, Martin D. Burke, Ian Dailey, Nagarjuna Palyam, David M. Knapp, Pulin Wang, Stephen A. Davis, Brice E. Uno, Kaitlyn C. Gray, US Patent 11,028,114. 2021

  • See also: AU Patent 2014332214, 2020 and 2019279928, 2020
  • See also: CA Patent 2925904, 2021
  • See also: CN ZL201480065533.6, 2019 and CN Patent ZL201910693627.2
  • See also: EPO 3055030, 2019
  • See also: JP 6600303, 2019
  • See also: KR 10-2321482, 2021 and 10-2548341, 2023
  • See also: NZ 719529, 2021
  • See also: SG 11201602570W, 2018
  • See also: BE/DK/DE/FR/IE/IT/ES/CH/GB/LI 3055030, 2018

82. Amphotericin B induces epithelial voltage responses in people with cystic fibrosis, Rajeev S. Chorghade, Bo Ram Kim, Janice L. Launspach, Philip H. Karp, Michael J. Welsh and Martin D. Burke Journal of Cystic Fibrosis 2020, 7 (5), 781-791 DOI: 10.1016/j.jcf.2020.11.01

81. COVID-19 Testing Strategies for Colleges and Universities National Academies of Sciences, Engineering, and Medicine.’ Washington, DC: The National Academies Press, 2020

80. Saliva-Based Molecular Testing for SARS-CoV-2 that Bypasses RNA Extraction, Diana Rose E. Ranoa, Robin L. Holland, Fadi G. Alnaji, Kelsie J. Green, Leyi Wang, Christopher Byron Brooke, Martin D. Burke, Timothy M. Fan, Paul Hergenrother Cold Spring Harbor Laboratory Press, 2020 DOI: 10.1101/2020.06.18.159434v1

79. Modular synthesis enables molecular ju-jitsu in the fight against antibiotic resistance, Daniel J. Blair and Martin D. Burke Nature 2020 586, 32-33 DOI: 10.1038/d41586-020-02565-1

78. A Mild Method for Making MIDA Boronates, Aidan M. Kelly, Peng-Jui Chen, Jenna Klubnick, Daniel J. Blair, and Martin D. Burke Organic Letters 2020, 22 (24), 9408-9414 DOI: 10.1021/acs.orglett.0c02449

77. Small Molecule Channels Harness Membrane Potential to Concentrate Potassium in trk1Δtrk2Δ Yeast, Jennifer Hou, Page N. Daniels, and Martin D. Burke ACS Chemical Biology 2020, 15 (6), 1575-1580 DOI: 10.1021/acschembio.0c00180

76. Protected Organoboronic Acids with Tunable-Reactivity, and Methods of Use Thereof Martin D. Burke, Michael J. Schmidt, Greg Morehouse, Robert W. Pipal, US Patent 10844081. 2020

75. Automated Synthesis of Small Molecules Using Chiral, Non-Racemic Boronates Eric P. Gillis, Martin D. Burke, Junqi Li, US Patent 10,752,577. 2020

74. Scalable Synthesis of Reduced Toxicity Derivative of Amphotericin B Martin D. Burke, Souvik Rakshit, Brice E. Uno, US Patent 10,683,318. 2020

  • See also: AU Patent 2021202949, 2023

73. A Computer Conquers Tactical Combinations, Daniel J. Blair and Martin D. Burke Chem. 2020, 6 (1), 12-13 DOI: 10.1016/j.chempr.2019.12.019

72. Modular Syntheses of Phenanthroindolizidine Natural Products, Young-In Jo, Martin D. Burke, and Cheol-Hong Cheon Organic Letters 2019, 21 (11), 4201-4204 DOI: 10.1021/acs.orglett.9b01397

71. Axial shielding of Pd(II) complexes enables perfect stereoretention in Suzuki-Miyaura cross-coupling of Csp3 boronic acids, Jonathan W. Lehmann, Ian T. Crouch, Daniel J. Blair, Melanie Trobe, Pulin Wang, Junqi Li and Martin D. Burke Nature Communications 2019, 10, 1263 DOI: 10.1038/s41467-019-09249-z

70. Small-molecule ion channels increase host defences in cystic fibrosis airway epithelia, Katrina A. Muraglia, Rajeev S. Chorghade, Bo Ram Kim, Xiao Xiao Tang, Viral S. Shah, Anthony S. Grillo, Page N. Daniels, Alexander G. Cioffi, Philip H. Karp, Lingyang Zhu, Michael J. Welsh and Martin D. Burke Nature 2019, 567, 405–408 DOI: 10.1038/s41586-019-1018-5

69. Stereoretentive Cross-Coupling of Boronic Acids Ian Crouch, Martin D. Burke, Andrea M. E. Palazzolo, Jonathan Lehmann, Claire L. Simons, US Patent 10,370,393. 2019

68. Automated Synthesis of Small Molecules Using Chiral, Non-Racemic Boronates Eric P. Gillis, Martin D. Burke, Junqi Li, US Patent 10,239,824. 2019

67. Amphotericin B Derivatives with Improved Therapeutic Index Justin Struble, Martin D. Burke, Ian Dailey, Nagarjuna Palyam, David M. Knapp, Pulin Wang, Stephen A. Davis, Brice E. Uno, Kaitlyn C. Gray, US Patent 10,323,057. 2019

66. FAM210B is an erythropoietin target and regulates erythroid heme synthesis by controlling mitochondrial iron import and ferrochelatase activity, Yvette Y. Yien, Jiahai Shi, Caiyong Chen, Jesmine T.M. Cheung, Anthony S. Grillo, Rishna Shrestha, Liangtao Li, Xuedi Zhang, Martin D. Kafina, Paul D. Kingsley, Matthew J. King, Julien Ablain, Hojun Li, Leonard I. Zon, James Palis, Martin D. Burke, Daniel E. Bauer, Stuart H. Orkin, Carla M. Koehler, John D. Phillips, Jerry Kaplan, Diane M. Ward, Harvey F. Lodish and Barry H. Paw Journal of Biological Chemistry 2018, 293, 19797-19811. DOI: 10.1074/jbc.RA118.002742

65. Peridinin Is an Exceptionally Potent and Membrane-Embedded Inhibitor of Bilayer Lipid Peroxidation, Hannah M.S. Haley, Adam G. Hill, Alexander I. Greenwood, Eric M. Woerly, Chad M. Rienstra, and Martin D. Burke Journal of the American Chemical Society 2018, 140 (45), 15227-15240 DOI: 10.1021/jacs.8b06933

64. The molecular industrial revolution: automated synthesis of small molecules, Melanie Trobe and Martin D. Burke Angewandte Chemie 2018, 57, 4192-4214 DOI: 10.1002/anie.201710482

63. Solid-State NMR of highly 13C-enriched cholesterol in lipid bilayers, Lisa A. Della Ripa, Zoe A. Petros, Alexander G. Cioffi, Dennis W. Piehl, Joseph M. Courtney, Martin D. Burke and Chad M. Rienstra Methods 2018, 138-139; 47-53. DOI: 10.1016/j.ymeth.2018.01.008

62. Towards the generalized iterative synthesis of small molecules, Jonathan W. Lehmann, Daniel J. Blair and Martin D. Burke Nature Reviews Chemistry 2018, 2, 0115 DOI: 10.1038/s41570-018-0115

61. Methods for Forming Protected Organoboronic Acids Eric P. Gillis, Martin D. Burke, Jenna A. Klubnick, Graham R. Dick, David M. Knapp, US Patent 9908900. 2018

60. Apparatus and Methods for the Automated Synthesis of Small Molecules Eric P. Gillis, Martin D. Burke, Steven G. Ballmer, US Patent 9862733. 2018

  • See also: EPO/FR/DE/IE/NL/CH/GB Patent 3018136, 2020
  • See also: JP Patent 6291641, 2018

59. Cross-Coupling of Unactivated Secondary Boronic Acids Ian Crouch, Martin D. Burke, Pulin Wang, US Patent 10072028. 2018

  • See also: EPO/DE/FR/GB Patent 3063154, 2023

58. Scalable Synthesis of Reduced Toxicity Derivative of Amphotericin B Martin D. Burke, Souvik Rakshit, Brice E. Uno, US Patent 10087206. 2018

  • See also: JP Patent 6755859, 2020
  • See also: AU Patent 2015331904, 2021

57. The Natural Productome, Andrea M. E. Palazzolo, Claire L. W. Simons, Martin D. Burke Proceedings of the National Academy of Sciences 2017, 114 (22) 5564-5566; DOI: 10.1073/pnas.1706266114

56. Restored iron transport by a small molecule promotes absorption and hemoglobinization in animals, Anthony S. Grillo, Anna M. SantaMaria, Martin D. Kafina, Alexander G. Cioffi, Nicholas C. Huston, Murui Han, Young Ah Seo, Yvette Y. Yien, Christopher Nardone, Archita V. Menon, James Fan, Dillon C. Svoboda, Jacob B. Anderson, John D. Hong, Bruno G. Nicolau, Kiran Subedi, Andrew A. Gewirth, Marianne Wessling-Resnick, Jonghan Kim, Barry H. Paw and Martin D. Burke Science, 2017, 356 608-615. DOI: 10.1126/science.aah3862

55. Amphotericin B Derivative with Reduced Toxicity Martin D. Burke, Brice E. Uno, US Patent 9738677. 2017

  • See also: EPO Patent EP3142672, 2019
  • See also: JP Patent 6543272, 2019
  • See also: CA Patent 2981288, 2022
  • See also: BE/DK/DE/FR/IE/IT/ES/CH/GB/LI Patent EP3142672

54. System for Controlling the Reactivity of Boronic Acids Eric P. Gillis, Martin
D. Burke, US Patent 9732102. 2017

53. Slow Release of Organoboronic Acids in Cross-Coupling Reactions Eric P. Gillis, Martin D. Burke, David M. Knapp, US Patent 9845317. 2017

52. MIDA Boronates Are Hydrolysed Fast and Slow by Two Different Mechanisms, Jorge A. Gonzalez, O. Maduka Ogba, Gregory F. Morehouse, Nicholas Rosson, Kendall N. Houk, Andrew G. Leach, Paul H.-Y. Cheong, Martin D. Burke and Guy C. Lloyd-Jones. Nature Chemistry 2016, 8, 1067-1075. DOI: 10.1038/nchem.2571

51. Methods for Forming Protected Organoboronic Acids Eric P. Gillis, Graham R. Dick, Martin D. Burke, David M. Knapp, Jenna A. Klubnick, US Patent 9353131. 2016

50. Slow Release of Organoboronic Acids in Cross-Coupling Reactions Eric P. Gillis, Martin D. Burke, David M. Knapp, US Patent 9328102. 2016

49. Automated Synthesis of Small Molecules Using Chiral, Non-Racemic Boronates Eric P. Gillis, Martin D. Burke, Junqi Li, US Patent 9388131. 2016

48. Apparatus and Methods for the Automated Synthesis of Small Molecules Martin D. Burke, Steven G. Ballmer, Eric P. Gillis, US Patent 9238597. 2016

  • See also: EPO/CH/DE/GB/FR/IE/NL/SE/ES/IT Patent 2596000, 2016
  • See also: JP Patent 6054867, 2015
  • See also: AU Patent 2011280890, 2015 and 2014256354, 2016

47. System for Controlling the Reactivity of Boronic Acids David M. Knapp, Martin D. Burke, Kaitlyn C. Gray, Eric P. Gillis, Suk Joong Lee, US Patent 9328127. 2016

  • See also: CH/DE/FR/GB/IE/IT/PT/ES/EPO Patent 2181103, 2015

46. Our Path to Less Toxic Amphotericins, Matthew M. Endo Alexander G. Cioffi, Martin D. Burke Synlett 2015, 27, 337. DOI: 10.1055/s-0035-1560800 Recipient of the Thieme IUPAC Prize in Synthetic Organic Chemistry.

45. C3-OH of Amphotericin B Plays an Important Role in Ion Conductance, Stephen A. Davis, Lisa A. Della Ripa, Lingbowei Hu, Alexander G. Cioffi, Taras V. Pogorelov, Chad M. Rienstra, and Martin D. Burke Journal of the American Chemical Society 2015 137 (48), 15102-15104 DOI: 10.1021/jacs.5b05766

44. Restored Physiology in Protein-Deficient Yeast by a Small Molecule Channel, Alexander G. Cioffi, Jennifer Hou, Anthony S. Grillo, Katrina A. Diaz, and Martin D. Burke Journal of the American Chemical Society 2015 137 (32), 10096-10099 DOI: 10.1021/jacs.5b05765

43. Nontoxic Antimicrobials that Evade Drug Resistance, Stephen A. Davis, Benjamin M. Vincent, Matthew M. Endo, Luke Whitesell, Karen Marchillo, David R. Andes, Susan Lindquist and Martin D. Burke. Nature Chemical Biology 2015, 11, 481-487. DOI: 10.1038/nchembio.1821

42. Synthesis of many different types of organic small molecules using one automated process, Junqi Li, Steven G. Ballmer, Eric P. Gillis, Seiko Fujii, Michael J. Schmidt, Andrea M. E. Palazzolo, Jonathan W. Lehmann, Greg F. Morehouse, and Martin D. Burke Science 2015, 347, 1221-1226 DOI: 10.1126/science.aaa5414

41. From Synthesis to Function via Iterative Assembly of N-Methyliminodiacetic Acid Boronate Building Blocks, Junqi Li, Anthony S. Grillo, and Martin D. Burke. Accounts of Chemical Research 2015 48 (8), 2297-2307 DOI: 10.1021/acs.accounts.5b00128

40. Slow Release of Organoboronic Acids in Cross-Coupling Reactions Eric P. Gillis, Martin D. Burke, David M. Knapp, US Patent 9006463. 2015

39. Automated Synthesis of Small Molecules Using Chiral, Non-Racemic Boronates Martin D. Burke, Eric P. Gillis, Junqi Li, US Patent 9012658. 2015

38. Synthesis of Most Polyene Natural Product Motifs Using Just Twelve Building Blocks and One Coupling Reaction, Eric M. Woerly, Jahnabi Roy, Martin D. Burke. Nature Chemistry 2014, 6, 484-491. DOI: 10.1038/nchem.1947

37. Amphotericin Forms an Extramembranous and Fungicidal Sterol Sponge, Thomas M. Anderson, Mary C. Clay, Alexander G. Cioffi, Katrina A. Diaz, Grant S. Hisao, Marcus D. Tuttle, Andrew J. Nieuwkoop, Gemma Comellas, Nashrah Maryum, Shu Wang, Brice E. Uno, Erin L. Wildeman, Tamir Gonen, Chad M. Rienstra, Martin D. Burke. Nature Chemical Biology 2014, 10, 400-406. DOI: 10.1038/nchembio.1496

36. (1-Bromovinyl)-MIDA boronate: a readily accessible and highly versatile building block for small molecule synthesis, Eric M. Woerly, Jonathan E. Miller, and Martin D. Burke Tetrahedron 2013, 69, 7732-7740. DOI: 10.1016/j.tet.2013.05.050

35. C2′-OH of Amphotericin B Plays an Important Role in Binding the Primary Sterol of Human Cells but Not Yeast Cells, Brandon C. Wilcock, Matthew M. Endo, Brice E. Uno, and Martin D. Burke Journal of the American Chemical Society 2013 135 (23), 8488-8491 DOI: 10.1021/ja403255s

34. Methods for Forming Protected Organoboronic Acids David M. Knapp, Martin D. Burke, Eric P. Gillis, Brice E. Uno, Graham R. Dick, Jenna A. Klubnick, US Patent 8557980. 2013

33. Electronic tuning of site-selectivity, Brandon C Wilcock 1, Brice E. Uno, Gretchen L. Bromann, Matthew J. Clark, Thomas M. Anderson and Martin D. Burke Nature Chemistry 2012, 4, 996-1003. DOI: 10.1038/nchem.1495

32. Amphotericin primarily kills yeast by simply binding ergosterol, Kaitlyn C. Gray, Daniel S. Palacios, Ian Dailey, Matthew M. Endo, Brice E. Uno, Brandon C. Wilcock, and Martin D. Burke Proceedings of the National Academy of Sciences U.S.A. 2012, 109, 2234-223 DOI: 10.1073/pnas.1117280109

31. A General Solution for the 2-Pyridyl Problem, Graham R. Dick, Eric M. Woerly and Martin D. Burke, Angewandte Chemie International Edition 2012, 51, 2667-2672 DOI: 10.1002/anie.201108608

30. System for Controlling the Reactivity of Boronic Acids Martin
D. Burke, David M. Knapp, Eric P. Gillis, Kaitlyn C. Gray, Suk Joong Lee, US Patent 8318983. 2012

29. Slow Release of Organoboronic Acids in Cross-Coupling Reactions David M. Knapp, Eric P. Gillis, Martin D. Burke, US Patent 9328102. 2012

28. Pinene-Derived Iminodiacetic Acid (PIDA): A Powerful Ligand for Stereoselective Synthesis and Iterative Cross-Coupling of C(sp3) Boronate Building Block, Junqi Li and Martin D. Burke Journal of the American Chemical Society 2011, 133 (35), 13774-13777 DOI: 10.1021/ja205912y

27. Total Synthesis of Synechoxanthin through Iterative Cross-Coupling, Seiko Fujii, Stephanie Y. Chang and Martin D. Burke Angewandte Chemie International Edition 2011, 50, 7862-7864. DOI: 10.1002/anie.201102688

26. Synthesis-enabled functional group deletions reveal key underpinnings of amphotericin B ion channel and antifungal activities, Daniel S. Palacios, Ian Dailey, David M. Siebert, Brandon C. Wilcock, and Martin D. Burke Proceedings of the National Academy of Sciences U.S.A. 2011, 108, 6733-6738. DOI: 10.1073/pnas.1015023108

25. (Z)-(2-Bromovinyl)-MIDA boronate: a readily accessible and highly versatile building block for small molecule synthesis, Eric M. Woerly, Justin R. Struble, Nagarjuna Palyam, Sean P. O’Hara, and Martin D. Burke Tetrahedron 2011, 67, 4333-4343. DOI: 10.1016/j.tet.2011.04.021

24. System for Controlling the Reactivity of Boronic Acids Martin
D. Burke, Eric P. Gillis, US Patent 8013203. 2011

23. A Simple and General Platform for Generating Stereochemically Complex Polyene Frameworks by Iterative Cross-Coupling, Suk Joong Lee, Thomas M. Anderson, Martin D. Burke Angewandte Chemie International Edition 2010, 49, 8860-8863. DOI: 10.1002/anie.201004911

22. Stereoretentive Suzuki−Miyaura Coupling of Haloallenes Enables Fully Stereocontrolled Access to (−)-Peridinin, Eric M. Woerly, Alan H. Cherney, Erin K. Davis, and Martin D. Burke Journal of the American Chemical Society 2010, 132 (20), 6941-6943 DOI: 10.1021/ja102721p

21. A General Method for Synthesis of 2-Heterocyclic N-Methyliminodiacetic Acid Boronates, Graham R. Dick, David M. Knapp, Eric P. Gillis, and Martin D. Burke Organic Letters 2010, 12 (10), 2314-2317 DOI: 10.1021/ol100671v

20. N-(Carboxymethyl)-N-methyl-glycine, Ian Dailey and Martin D. Burke Encyclopedia of Reagents for Organic Synthesis 2010, DOI: 10.1002/047084289X.rn01228

19. Ethynyl MIDA boronate: a readily accessible and highly versatile building block for small molecule synthesis, Justin R. Struble, Suk Joong Lee, and Martin D. Burke Tetrahedron 2010, 66, 4710-4718 DOI: 10.1016/j.tet.2010.04.020

18. A general solution for unstable boronic acids: Slow-release cross-coupling from air-stable MIDA boronates, David M. Knapp, Eric P. Gillis, Martin D. Burke Journal of the American Chemical Society, 2009 131(20), 6961-6963 DOI: 10.1021/ja901416p

17. Vinyl MIDA Boronate: a readily accessible and highly versatile building block for small molecule synthesis, Brice E. Uno, Eric P. Gillis, Martin D. Burke Tetrahedron 2009, 65, 3130-3138 DOI: 10.1016/j.tet.2008.11.010

16. Flexible tetracycline synthesis yields promising antibiotics, Martin D. Burke Nature Chemical Biology 2009, 5, 77-79 DOI: 10.1038/nchembio0209-77

15. B-Protected Haloboronic Acids for Iterative Cross-Coupling, Steven G. Ballmer, Eric P. Gillis, Martin D. Burke, Daniel Morton and Huw M.L. Davies Organic Syntheses 2009, 86, 344-359 DOI: 10.1002/0471264229.os086.33

14. Iterative Cross-Coupling with MIDA Boronates: Towards a General Platform for Small Molecule Synthesis, Eric P. Gillis and Martin D. Burke Aldrichimica Acta. 2009, 42(1): 17–27.

13. Multistep Synthesis of Complex Boronic Acids from Simple MIDA Boronates, Eric P. Gillis and Martin D. Burke Journal of the American Chemical Society 2008, 130 (43), 14084-14085 DOI: 10.1021/ja8063759

12. Simple, Efficient, and Modular Syntheses of Polyene Natural Products via Iterative Cross-Coupling, Suk Joong Lee, Kaitlyn C. Gray, James S. Paek, and Martin D. Burke Journal of the American Chemical Society 2008, 130 (2), 466-468 DOI: 10.1021/ja078129x

11. A Post-PKS Oxidation of the Amphotericin B Skeleton Predicted to be Critical for Channel Formation Is Not Required for Potent Antifungal Activity, Daniel S. Palacios, Thomas M. Anderson, and Martin D. Burke Journal of the American Chemical Society 2007, 129 (45), 13804-13805 DOI: 10.1021/ja075739o

10. A Simple and Modular Strategy for Small Molecule Synthesis:  Iterative Suzuki−Miyaura Coupling of B-Protected Haloboronic Acid Building Blocks, Eric P. Gillis and Martin D. Burke Journal of the American Chemical Society 2007, 129 (21), 6716-6717 DOI: 10.1021/ja0716204

9. A Synthesis Strategy Yielding Skeletally Diverse Small Molecules Combinatorically, Martin D. Burke, Eric M. Berger, and Stuart L. Schreiber Journal of the American Chemical Society 2004 126 (43), 14095-14104 DOI: 10.1021/ja0457415

8. A planning strategy for diversity-oriented synthesis, Martin D. Burke and Stuart L. Schreiber Angewandte Chemie International Edition 2004, 43, 46-58. DOI: 10.1002/anie.200300626

7. Generating Diverse Skeletons of Small Molecules Combinatorially, Martin D. Burke, Eric M. Berger, and Stuart L. Schreiber Science 2003, 302, 613-618 DOI: 10.1126/science.1089946

6. Chemoenzymatic Route to Macrocyclic Hybrid Peptide/Polyketide-like Molecules, Rahul M. Kohli, Martin D. Burke, Junhua Tao, and Christopher T. Walsh Journal of the American Chemical Society 2003, 125 (24), 7160-7161 DOI: 10.1021/ja0352202

5. Teaching Target-Oriented and Diversity-Oriented Organic Synthesis at Harvard University, Martin D. Burke and Gojko Lalic Chemistry and Biology 2002, 9, 535-541. DOI: 10.1016/S1074-5521(02)00143-6

4. Conformationally restricted hybrid analogues of the hormone 1 alpha,25-dihydroxyvitamin D (3): design, synthesis, and biological evaluation, M. Christina White, Martin D. Burke, Sarah Peleg, Patrick Dolan, Thomas W. Kensler, Henry Brem, and Gary H. Posner Bioorganic & Medicinal Chemistry 2001, 9, 1691-1699 DOI: 10.1016/s0968-0896(01)00087-6

3. Central Nervous System, Drug Delivery to Treat, Martin D. Burke, Henry Brem, and Robert Langer in The Encyclopedia of Controlled Drug Delivery The Encyclopedia of Controlled Drug Delivery. Mathiowitz, E., Ed.; John Wiley and Sons., Vol. 1, 1999, 184-212.

2. Noncalcemic, Antiproliferative, Transcriptionally Active, 24-Fluorinated Hybrid Analogues of the Hormone 1α,25-Dihydroxyvitamin D3. Synthesis and Preliminary Biological Evaluation, Gary H. Posner, Jae Kyoo Lee, Qiang Wang, Sara Peleg, Martin D. Burke, Henry Brem, Patrick Dolan, and Thomas W. Kensler Journal of Medicinal Chemistry 1998, 41 (16), 3008-3014 DOI: 10.1021/jm980031t

1. Polymer-Controlled Drug Delivery: An Overview for the Clinician, Justin Hanes and Martin D. Burke. Hospital Pharmacist Report. December 1997 2-11.