Publications

Browse our peer-reviewed publications.

The following is a representative selection.
For a comprehensive list, visit Google Scholar.

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Recent Papers

Bonding carbons iteratively.
Martin D. Burke
Science 393, 763-764(2026).
https://doi.org/10.1126/science.aeg5569

Democratizing Machine Learning in Chemistry with Community-Engaged Test Sets.
Wu, J. L.; Friday, D. M.; Hwang, C.; Yi, S.; Torres-Flores, T. C.; Burke, M. D.; Diao, Y.; Schroeder, C. M.; Jackson, N. E.*
Digital Discovery 2026, 5, 304–309. 
https://doi.org/10.1039/D5DD00424A

Molecular Prosthetics for CFTR Designed for Anion Selectivity Outperform Amphotericin B in Cultured Cystic Fibrosis Airway Epithelia.
Marin-Toledo, J. P.; Greenan, D.; Celis, N.; Haske, L.; Lewandowska, A.; …
bioRxiv 2025, 2025.08.28.671923.
https://doi.org/10.1101/2025.08.28.671923.

Molecular Prosthetics and CFTR Modulators Additively Increase Secretory HCO₃⁻ Flux in Cystic Fibrosis Airway Epithelia.
Celis, N.; Miller, D. P.; Tarara, T. E.; Weers, J. G.; Thornell, I. M.; Welsh, M. J.; Burke, M. D.; …
ACS Chem. Biol. 2025.
https://doi.org/10.1021/acschembio.5c00473.

Illuminating the Interface of Blocc Chemistry and Data Science: An Introduction to K-Nearest Neighbor Analysis and K-Medoids Clustering.
Green, N. M.; Putnam, J. L. B.; Hammond, R. I.; Angello, N. H.; Planey, J.; Brandt, D.; Andino Martinez, J.; Hummel, T.; Gunasekera, B.; Switzky, R.; Desmond, S.; Burke, M. D.
J. Chem. Educ. 2025, 102 (12), 5273–5281.
https://doi.org/10.1021/acs.jchemed.5c00796.

Illuminating the Interface of Blocc Chemistry and Data Science: An Introduction to K-Nearest Neighbor Analysis and K-Medoids Clustering.
Green, N. M.; Putnam, J. L. B.; Hammond, R. I.; Angello, N. H.; Planey, J.; Brandt, D.; Andino Martinez, J.; Hummel, T.; Gunasekera, B.; Switzky, R.; Desmond, S.; Burke, M. D.
J. Chem. Educ. 2025, ASAP.
https://doi.org/10.1021/acs.jchemed.5c00796

mCLM: A Modular Chemical Language Model that Generates Functional and Makeable Molecules.
Edwards, C.; Han, C.; Lee, G.; Nguyen, T.; Jin, B.; Prasad, C. K.; Szymkuć, S.; …
arXiv 2025, arXiv:2505.12565.
https://doi.org/10.48550/arXiv.2505.12565.

Catalytic Allylation of Native Hexoses and Pentoses in Water with Indium.
Adak, T.; Menard, T.; Albritton, M.; Florit, F.; Burke, M. D.; Jensen, K. F.; …
Nature 2025, 640, 94–99.
https://doi.org/10.1038/s41586-025-08690-z.

Automated Iterative N–C and C–C Bond Formation.
Tyrikos-Ergas, T.; Agiakloglou, S.; LaPorte, A. J.; Wang, W.; Chan, C. K.; Wells, C. E.; …
Angew. Chem., Int. Ed. 2025, 64, e202509974.
https://doi.org/10.1002/anie.202509974.

Farm: Functional Group-Aware Representations for Small Molecules.
Nguyen, T.; Huang, K. H.; Liu, G.; Burke, M. D.; Diao, Y.; Ji, H.
arXiv 2024, arXiv:2410.02082.
https://doi.org/10.48550/arXiv.2410.02082.

Closed-Loop Transfer Enables Artificial Intelligence to Yield Chemical Knowledge.
Angello, N. H.; Friday, D. M.; Hwang, C.; Yi, S.; Cheng, A. H.; Torres-Flores, T. C.; …
Nature 2024, 633, 351–358.
https://doi.org/10.1038/s41586-024-07892-1.

Rapid Automated Iterative Small-Molecule Synthesis.
Wang, W.; Angello, N. H.; Blair, D. J.; Tyrikos-Ergas, T.; Krueger, W. H.; …
Nat. Synth. 2024, 3 (8), 1031–1038.
https://doi.org/10.1038/s44160-024-00601-w.

Delocalized, Asynchronous, Closed-Loop Discovery of Organic Laser Emitters.
Strieth-Kalthoff, F.; Hao, H.; Rathore, V.; Derasp, J.; Gaudin, T.; Angello, N. H.; …
Science 2024, 384 (6697), eadk9227.
https://doi.org/10.1126/science.adk9227.

Molecule Maker Lab Institute: Accelerating, Advancing, and Democratizing Molecular Innovation.
Martin D. Burke, Scott E. Denmark, Ying Diao, Jiawei Han, Rachel Switzky, and Huimin Zhao
AI Mag. 2024, 45 (1), 117–123.
https://doi.org/10.1002/aaai.12154.

Computational Prediction of Complex Cationic Rearrangement Outcomes.
Klucznik, T.; Syntrivanis, L.-D.; Baś, S.; Mikulak-Klucznik, B.; Moskal, M.; …
Nature 2024, 625, 508–515.
https://doi.org/10.1038/s41586-023-06854-3.

Minimizing Higher-Order Aggregation Maximizes Iron Mobilization by Small Molecules.
Blake, A. D.; Chao, J.; SantaMaria, A. M.; Snead, N. M.; Matje, D. M.; Green, K. J.; …
Nat. Chem. Biol. 2024, 20 (10), 1282–1293.
https://doi.org/10.1038/s41589-024-01596-3.

Reaction Miner: An Integrated System for Chemical Reaction Extraction from Textual Data.
Zhong, M.; Ouyang, S.; Jiao, Y.; Kargupta, P.; Luo, L.; Shen, Y.; Zhou, B.; Zhong, X.; …
EMNLP Proceedings 2023.
https://doi.org/10.18653/v1/2023.emnlp-demo.36.

Tuning Sterol Extraction Kinetics Yields a Renal-Sparing Polyene Antifungal.
Maji, A.; Soutar, C. P.; Zhang, J.; Lewandowska, A.; Uno, B. E.; Yan, S.; …
Nature 2023, 623 (7989), 1079–1085.
https://doi.org/10.1038/s41586-023-06710-4.

MIDA- and TIDA-Boronates Stabilize α-Radicals Through B–N Hyperconjugation.
LaPorte, A. J.; Feldner, J. E.; Spies, J. C.; Maher, T. J.; Burke, M. D.
Angew. Chem., Int. Ed. 2023, 135 (40), e202309566.
https://doi.org/10.1002/anie.202309566.

Amphotericin B Cystetic for Inhalation (CM001): A Randomized, Double-Blind, Placebo-Controlled, Single-Ascending-Dose Study in Healthy Volunteers.
Burke, M.; Welsh, M.; Weers, J.; Sellwood, C.; Reisner, C.
J. Cystic Fibrosis 2023, 22, S129.

Segmental Dynamics of Membranous Cholesterol Are Coupled.
Della Ripa, L. A.; Courtney, J. M.; Phinney, S. M.; Borcik, C. G.; Burke, M. D.; …
J. Am. Chem. Soc. 2023, 145 (28), 15043–15048.
https://doi.org/10.1021/jacs.3c01775.

SynerGPT: In-Context Learning for Personalized Drug Synergy Prediction and Drug Design.
Edwards, C.; Naik, A.; Khot, T.; Burke, M. D.; Ji, H.; Hope, T.
bioRxiv 2023, 2023.07.06.54775.
https://doi.org/10.1101/2023.07.06.547759.

Robust Model-Based Optimization for Challenging Fitness Landscapes.
Ghaffari, S.; Saleh, E.; Schwing, A. G.; Wang, Y.-X.; Burke, M. D.; Sinha, S.
arXiv 2023, arXiv:2305.13650.
https://doi.org/10.48550/arXiv.2305.13650.

A Materials Acceleration Platform for Organic Laser Discovery.
Wu, T. C.; Aguilar-Granda, A.; Hotta, K.; Yazdani, S. A.; Pollice, R.; Vestfrid, J.; …
Adv. Mater. 2023, 35 (6), 2207070.
https://doi.org/10.1002/adma.202207070.

Closed-Loop Optimization of General Reaction Conditions for Heteroaryl Suzuki–Miyaura Coupling.
Angello, N. H.; Rathore, V.; Beker, W.; Wołos, A.; Jira, E. R.; Roszak, R.; Wu, T. C.; Aspuru-Guzik, A.; Grzybowski, B. A.; Burke, M. D.; et al.
Science 2022, 378 (6618), 399–405.
https://doi.org/10.1126/science.adc8743. 

Automated Iterative Csp³–C Bond Formation.
Blair, D. J.; Chitti, S.; Trobe, M.; Kostyra, D. M.; Haley, H. M. S.; Hansen, R. L.; et al.; Burke, M. D.
Nature 2022, 604, 92–97.
https://doi.org/10.1038/s41586-022-04491-w. 

Digitizing Chemical Synthesis in 3D-Printed Reactionware.
Bubliauskas, A.; Blair, D. J.; Powell-Davies, H.; Kitson, P. J.; Burke, M. D.; Cronin, L.
Angew. Chem., Int. Ed. 2022, 134 (24), e202116108.
https://doi.org/10.1002/anie.202116108. 

Machine Learning May Sometimes Simply Capture Literature Popularity Trends: A Case Study of Heterocyclic Suzuki–Miyaura Coupling.
Beker, W.; Roszak, R.; Wołos, A.; Angello, N. H.; Rathore, V.; Burke, M. D.; Grzybowski, B. A.
J. Am. Chem. Soc. 2022, 144 (11), 4819–4827.
https://doi.org/10.1021/jacs.1c12005. 

Iterations from the Chemical Cosmos.
Loving, D. C.; Burke, M. D.
Nat. Synth. 2022, 1, 11–12.
https://doi.org/10.1038/s44160-021-00014-z. 

Mitigation of SARS-CoV-2 Transmission at a Large Public University.
Ranoa, D. R. E.; Holland, R. L.; Alnaji, F. G.; Green, K. J.; Wang, L.; et al.; Burke, M. D.
Nat. Commun. 2022, 13, 3207.
https://doi.org/10.1038/s41467-022-30833-3. 

Using Automated Synthesis to Understand the Role of Side Chains on Molecular Charge Transport.
Li, S.; Jira, E. R.; Angello, N. H.; Li, J.; Yu, H.; Moore, J. S.; Diao, Y.; Burke, M. D.; Schroeder, C. M.
Nat. Commun. 2022, 13, 2102.
https://doi.org/10.1038/s41467-022-29796-2. 

A Small Molecule Redistributes Iron in Ferroportin-Deficient Mice and Patient-Derived Primary Macrophages.
Ekaputri, S.; Choi, E.-K.; Sabelli, M.; Aring, L.; Green, K. J.; Chang, J. O.; Bao, K.; Burke, M. D.; Seo, Y.-A.
Proc. Natl. Acad. Sci. U.S.A. 2022, 119, e2121400119.
https://doi.org/10.1073/pnas.2121400119. 

Targeting Fungal Membrane Homeostasis with Imidazopyrazoindoles Impairs Azole Resistance and Biofilm Formation.
Revie, N. M.; Iyer, K. R.; Maxson, M. E.; Zhang, J.; Yan, S.; Fernandes, C. M.; Burke, M. D.; et al.
Nat. Commun. 2022, 13, 3634.
https://doi.org/10.1038/s41467-022-31308-1. 

Preparation of MIDA anhydride and Reaction with Boronic Acids.
Kelly, A. M.; Chen, P. J.; Klubnick, J.; Blair, D. J.; Burke, M. D.
Org. Synth. 2022, 99, 92.
https://doi.org/10.15227/orgsyn.099.0092. 

Fungicidal Amphotericin B Sponges Are Assemblies of Staggered Asymmetric Homodimers Encasing Large Void Volumes.
Lewandowska, A.; Soutar, C. P.; Greenwood, A. I.; Nimerovsky, E.; De Lio, A. M.; Burke, M. D.; Rienstra, C. M.; et al.
Nat. Struct. Mol. Biol. 2021, 28 (12), 972–981.
https://doi.org/10.1038/s41594-021-00685-4. 

Chemical-Reaction-Aware Molecule Representation Learning.
Wang, H.; Li, W.; Jin, X.; Cho, K.; Ji, H.; Han, J.; Burke, M. D.
arXiv 2021, arXiv:2109.09888.
https://doi.org/10.48550/arXiv.2109.09888. 

Transition between Nonresonant and Resonant Charge Transport in Molecular Junctions.
Li, S.; Yu, H.; Li, J.; Angello, N. H.; Jira, E. R.; Li, B.; Burke, M. D.; Moore, J. S.
Nano Lett. 2021, 21 (19), 8340–8347.
https://doi.org/10.1021/acs.nanolett.1c02915. 

Well-Tolerated Amphotericin B Derivatives That Effectively Treat Visceral Leishmaniasis.
Morelle, C.; Mukherjee, A.; Zhang, J.; Fani, F.; Khandelwal, A.; Gingras, H.; Burke, M. D.; Ouellette, M.
ACS Infect. Dis. 2021, 7 (8), 2472–2482.
https://doi.org/10.1021/acsinfecdis.1c00245. 

Sterol Sponge Mechanism Is Conserved for Glycosylated Polyene Macrolides.
Guo, X.; Zhang, J.; Li, X.; Xiao, E.; Lange, J. D.; Rienstra, C. M.; Burke, M. D.; Mitchell, D. A.
ACS Cent. Sci. 2021, 7 (5), 781–791.
https://doi.org/10.1021/acscentsci.1c00148. 

Modular Synthesis Enables Molecular Ju-Jitsu in the Fight Against Antibiotic Resistance.
Blair, D. J.; Burke, M. D.
Nature 2020, 586, 32–33.
https://doi.org/10.1038/d41586-020-02565-1. 

A Mild Method for Making MIDA Boronates.
Kelly, A. M.; Chen, P. J.; Klubnick, J.; Blair, D. J.; Burke, M. D.
Org. Lett. 2020, 22 (24), 9408–9414.
https://doi.org/10.1021/acs.orglett.0c02449.

Amphotericin B Induces Epithelial Voltage Responses in People with Cystic Fibrosis.
Chorghade, R. S.; Kim, B. R.; Launspach, J. L.; Karp, P. H.; Welsh, M. J.; Burke, M. D.
J. Cyst. Fibros. 2020, 19 (5), 781–791.
https://doi.org/10.1016/j.jcf.2020.11.018.

Saliva-Based Molecular Testing for SARS-CoV-2 That Bypasses RNA Extraction.
Ranoa, D. R. E.; Holland, R. L.; Alnaji, F. G.; Green, K. J.; Wang, L.; Brooke, C. B.; Burke, M. D.; et al.
bioRxiv 2020, 2020.06.18.159434.
https://doi.org/10.1101/2020.06.18.159434. 

Small Molecule Channels Harness Membrane Potential to Concentrate Potassium in trk1Δtrk2Δ Yeast.
Hou, J.; Daniels, P. N.; Burke, M. D.
ACS Chem. Biol. 2020, 15 (6), 1575–1580.
https://doi.org/10.1021/acschembio.0c00180. 

Modular Syntheses of Phenanthroindolizidine Natural Products.
Jo, Y.-I.; Burke, M. D.; Cheon, C.-H.
Org. Lett. 2019, 21 (11), 4201–4204.
https://doi.org/10.1021/acs.orglett.9b01397. 

Axial Shielding of Pd(II) Complexes Enables Perfect Stereoretention in Suzuki–Miyaura Cross-Coupling of Csp³ Boronic Acids.
Lehmann, J. W.; Crouch, I. T.; Blair, D. J.; Trobe, M.; Wang, P.; Li, J.; Burke, M. D.
Nat. Commun. 2019, 10, 1263.
https://doi.org/10.1038/s41467-019-09249-z. 

Small-Molecule Ion Channels Increase Host Defences in Cystic Fibrosis Airway Epithelia.
Muraglia, K. A.; Chorghade, R. S.; Kim, B. R.; Tang, X. X.; Shah, V. S.; Grillo, A. S.; Daniels, P. N.; Cioffi, A. G.; Karp, P. H.; Zhu, L.; Welsh, M. J.; Burke, M. D.
Nature 2019, 567, 405–408.
https://doi.org/10.1038/s41586-019-1018-5. 

FAM210B Is an Erythropoietin Target and Regulates Erythroid Heme Synthesis by Controlling Mitochondrial Iron Import and Ferrochelatase Activity.
Yien, Y. Y.; Shi, J.; Chen, C.; Cheung, J. T. M.; Grillo, A. S.; Shrestha, R.; Li, L.; Zhang, X.; et al.; Burke, M. D.
J. Biol. Chem. 2019, 293 (51), 19797–19811.
https://doi.org/10.1074/jbc.RA118.002742.

Stereoretentive Cross-Coupling of Boronic Acids.
Burke, M. D.; Crouch, I.; Lehmann, J.; Palazzolo, A.; Simons, C.; et al.
U.S. Patent 10,370,393, 2019.

Peridinin Is an Exceptionally Potent and Membrane-Embedded Inhibitor of Bilayer Lipid Peroxidation.
Haley, H. M. S.; Hill, A. G.; Greenwood, A. I.; Woerly, E. M.; Rienstra, C. M.; Burke, M. D.
J. Am. Chem. Soc. 2018, 140 (45), 15227–15240.
https://doi.org/10.1021/jacs.8b06933. 

The Molecular Industrial Revolution: Automated Synthesis of Small Molecules.
Trobe, M.; Burke, M. D.
Angew. Chem., Int. Ed. 2018, 57, 4192–4214.
https://doi.org/10.1002/anie.201710482. 

Towards the Generalized Iterative Synthesis of Small Molecules.
Lehmann, J. W.; Blair, D. J.; Burke, M. D.
Nat. Rev. Chem. 2018, 2, 0115.
https://doi.org/10.1038/s41570-018-0115. 

Solid-State NMR of Highly 13C-Enriched Cholesterol in Lipid Bilayers.
Della Ripa, L. A.; Petros, Z. A.; Cioffi, A. G.; Piehl, D. W.; Courtney, J. M.; Burke, M. D.; Rienstra, C. M.
Methods 2018, 138–139, 47–53.
https://doi.org/10.1016/j.ymeth.2018.01.008. 

Cross-Coupling of Unactivated Secondary Boronic Acids.
Burke, M. D.; Wang, P.; Crouch, I.
U.S. Patent 10,072,028, 2018.

The Natural Productome.
Palazzolo, A. M. E.; Simons, C. L. W.; Burke, M. D.
Proc. Natl. Acad. Sci. U.S.A. 2017, 114 (22), 5564–5566.
https://doi.org/10.1073/pnas.1706266114. 

Restored Iron Transport by a Small Molecule Promotes Absorption and Hemoglobinization in Animals.
Grillo, A. S.; SantaMaria, A. M.; Kafina, M. D.; Cioffi, A. G.; Huston, N. C.; et al.; Burke, M. D.
Science 2017, 356, 608–615.
https://doi.org/10.1126/science.aah3862. 

MIDA Boronates Are Hydrolysed Fast and Slow by Two Different Mechanisms.
Gonzalez, J. A.; Ogba, O. M.; Morehouse, G. F.; Rosson, N.; Houk, K. N.; Leach, A. G.; Burke, M. D.; Lloyd-Jones, G. C.
Nat. Chem. 2016, 8, 1067–1075.
https://doi.org/10.1038/nchem.2571.

Our Path to Less Toxic Amphotericins.
Endo, M. M.; Cioffi, A. G.; Burke, M. D.
Synlett 2016, 27 (3), 337–354.
https://doi.org/10.1055/s-0035-1560800. 

C3-OH of Amphotericin B Plays an Important Role in Ion Conductance.
Davis, S. A.; Della Ripa, L. A.; Hu, L.; Cioffi, A. G.; Pogorelov, T. V.; Rienstra, C. M.; Burke, M. D.
J. Am. Chem. Soc. 2015, 137 (48), 15102–15104.
https://doi.org/10.1021/jacs.5b05766. 

Restored Physiology in Protein-Deficient Yeast by a Small Molecule Channel.
Cioffi, A. G.; Hou, J.; Grillo, A. S.; Diaz, K. A.; Burke, M. D.
J. Am. Chem. Soc. 2015, 137 (32), 10096–10099.
https://doi.org/10.1021/jacs.5b05765. 

Nontoxic Antimicrobials That Evade Drug Resistance.
Davis, S. A.; Vincent, B. M.; Endo, M. M.; Whitesell, L.; Marchillo, K.; Andes, D. R.; Lindquist, S.; Burke, M. D.
Nat. Chem. Biol. 2015, 11, 481–487.
https://doi.org/10.1038/nchembio.1821. 

Synthesis of Many Different Types of Organic Small Molecules Using One Automated Process.
Li, J.; Ballmer, S. G.; Gillis, E. P.; Fujii, S.; Schmidt, M. J.; Palazzolo, A. M. E.; Lehmann, J. W.; Morehouse, G. F.; Burke, M. D.
Science 2015, 347, 1221–1226.
https://doi.org/10.1126/science.aaa5414. 

From Synthesis to Function via Iterative Assembly of N-Methyliminodiacetic Acid Boronate Building Blocks.
Li, J.; Grillo, A. S.; Burke, M. D.
Acc. Chem. Res. 2015, 48 (8), 2297–2307.
https://doi.org/10.1021/acs.accounts.5b00128. 

Synthesis of Most Polyene Natural Product Motifs Using Just Twelve Building Blocks and One Coupling Reaction.
Woerly, E. M.; Roy, J.; Burke, M. D.
Nat. Chem. 2014, 6, 484–491.
https://doi.org/10.1038/nchem.1947. 

Amphotericin Forms an Extramembranous and Fungicidal Sterol Sponge.
Anderson, T. M.; Clay, M. C.; Cioffi, A. G.; Diaz, K. A.; Hisao, G.; Tuttle, M. D.; Nieuwkoop, A. J.; Comellas, G.; Maryum, N.; Wang, S.; Uno, B. E.; Wildeman, E. L.; Gonen, T.; Rienstra, C. M.; Burke, M. D.
Nat. Chem. Biol. 2014, 10, 400–406.
https://doi.org/10.1038/nchembio.1496. 

(1-Bromovinyl)-MIDA Boronate: A Readily Accessible and Highly Versatile Building Block for Small-Molecule Synthesis.
Woerly, E. M.; Miller, J. E.; Burke, M. D.
Tetrahedron 2013, 69 (36), 7732–7740.
https://doi.org/10.1016/j.tet.2013.05.050. 

C2′-OH of Amphotericin B Plays an Important Role in Binding the Primary Sterol of Human Cells but Not Yeast Cells.
Wilcock, B. C.; Endo, M. M.; Uno, B. E.; Burke, M. D.
J. Am. Chem. Soc. 2013, 135 (23), 8488–8491.
https://doi.org/10.1021/ja403255s. 

Electronic Tuning of Site-Selectivity.
Wilcock, B. C.; Uno, B. E.; Bromann, G. L.; Clark, M. J.; Anderson, T. M.; Burke, M. D.
Nat. Chem. 2012, 4, 996–1003.
https://doi.org/10.1038/nchem.1495. 

Amphotericin Primarily Kills Yeast by Simply Binding Ergosterol.
Gray, K. C.; Palacios, D. S.; Dailey, I.; Endo, M. M.; Uno, B. E.; Wilcock, B. C.; Burke, M. D.
Proc. Natl. Acad. Sci. U.S.A. 2012, 109 (7), 2234–2239.
https://doi.org/10.1073/pnas.1117280109. 

A General Solution for the 2-Pyridyl Problem.
Dick, G. R.; Woerly, E. M.; Burke, M. D.
Angew. Chem., Int. Ed. 2012, 51, 2667–2672.
https://doi.org/10.1002/anie.201108608. 

Pinene-Derived Iminodiacetic Acid (PIDA): A Powerful Ligand for Stereoselective Synthesis and Iterative Cross-Coupling of C(sp³) Boronate Building Blocks.
Li, J.; Burke, M. D.
J. Am. Chem. Soc. 2011, 133 (35), 13774–13777.
https://doi.org/10.1021/ja205912y. 

Total Synthesis of Synechoxanthin through Iterative Cross-Coupling.
Fujii, S.; Chang, S. Y.; Burke, M. D.
Angew. Chem., Int. Ed. 2011, 50, 7862–7864.
https://doi.org/10.1002/anie.201102688. 

Synthesis-Enabled Functional Group Deletions Reveal Key Underpinnings of Amphotericin B Ion Channel and Antifungal Activities.
Palacios, D. S.; Dailey, I.; Siebert, D. M.; Wilcock, B. C.; Burke, M. D.
Proc. Natl. Acad. Sci. U.S.A. 2011, 108, 6733–6738.
https://doi.org/10.1073/pnas.1015023108. 

(Z)-(2-Bromovinyl)-MIDA Boronate: A Readily Accessible and Highly Versatile Building Block for Small Molecule Synthesis.
Woerly, E. M.; Struble, J. R.; Palyam, N.; O’Hara, S. P.; Burke, M. D.
Tetrahedron 2011, 67, 4333–4343.
https://doi.org/10.1016/j.tet.2011.04.021. 

A Simple and General Platform for Generating Stereochemically Complex Polyene Frameworks by Iterative Cross-Coupling.
Lee, S. J.; Anderson, T. M.; Burke, M. D.
Angew. Chem., Int. Ed. 2010, 49, 8860–8863.
https://doi.org/10.1002/anie.201004911.

Stereoretentive Suzuki–Miyaura Coupling of Haloallenes Enables Fully Stereocontrolled Access to (–)-Peridinin.
Woerly, E. M.; Cherney, A. H.; Davis, E. K.; Burke, M. D.
J. Am. Chem. Soc. 2010, 132 (20), 6941–6943.
https://doi.org/10.1021/ja102721p. 

A General Method for Synthesis of 2-Heterocyclic N-Methyliminodiacetic Acid Boronates.
Dick, G. R.; Knapp, D. M.; Gillis, E. P.; Burke, M. D.
Org. Lett. 2010, 12 (10), 2314–2317.
https://doi.org/10.1021/ol100671v. 

N-(Carboxymethyl)-N-Methylglycine.
Dailey, I.; Burke, M. D.
Encyclopedia of Reagents for Organic Synthesis 2010.
https://doi.org/10.1002/047084289X.rn01228. 

Ethynyl MIDA Boronate: A Readily Accessible and Highly Versatile Building Block for Small-Molecule Synthesis.
Dick, G. R.; Knapp, D. M.; Gillis, E. P.; Burke, M. D.
Tetrahedron 2010, 66, 4710–4718.
https://doi.org/10.1016/j.tet.2010.04.020. 

A General Solution for Unstable Boronic Acids: Slow-Release Cross-Coupling from Air-Stable MIDA Boronates.
Knapp, D. M.; Gillis, E. P.; Burke, M. D.
J. Am. Chem. Soc. 2009, 131 (20), 6961–6963.
https://doi.org/10.1021/ja901416p. 

Vinyl MIDA Boronate: A Readily Accessible and Highly Versatile Building Block for Small Molecule Synthesis.
Uno, B. E.; Gillis, E. P.; Burke, M. D.
Tetrahedron 2009, 65, 3130–3138.
https://doi.org/10.1016/j.tet.2008.11.010.

Flexible Tetracycline Synthesis Yields Promising Antibiotics.
Burke, M. D.
Nat. Chem. Biol. 2009, 5, 77–79.
https://doi.org/10.1038/nchembio0209-77. 

B-Protected Haloboronic Acids for Iterative Cross-Coupling.
Ballmer, S. G.; Gillis, E. P.; Burke, M. D.; Morton, D.; Davies, H. M. L.
Org. Synth. 2009, 86, 344–359.
https://doi.org/10.15227/orgsyn.086.0344. 

Iterative Cross-Coupling with MIDA Boronates: Towards a General Platform for Small-Molecule Synthesis.
Gillis, E. P.; Burke, M. D.
Aldrichimica Acta 2009, 42 (1), 17–27.

Multistep Synthesis of Complex Boronic Acids from Simple MIDA Boronates.
Gillis, E. P.; Burke, M. D.
J. Am. Chem. Soc. 2008, 130 (43), 14084–14085.
https://doi.org/10.1021/ja8063759. 

Simple, Efficient, and Modular Syntheses of Polyene Natural Products via Iterative Cross-Coupling.
Lee, S. J.; Gray, K. C.; Paek, J. S.; Burke, M. D.
J. Am. Chem. Soc. 2008, 130 (2), 466–468.
https://doi.org/10.1021/ja078129x. 

A Post-PKS Oxidation of the Amphotericin B Skeleton Predicted to Be Critical for Channel Formation Is Not Required for Potent Antifungal Activity.
Palacios, D. S.; Anderson, T. M.; Burke, M. D.
J. Am. Chem. Soc. 2007, 129 (45), 13804–13805.
https://doi.org/10.1021/ja075739o. 

A Simple and Modular Strategy for Small Molecule Synthesis: Iterative Suzuki–Miyaura Coupling of B-Protected Haloboronic Acid Building Blocks.
Gillis, E. P.; Burke, M. D.
J. Am. Chem. Soc. 2007, 129 (21), 6716–6717.
https://doi.org/10.1021/ja0716204. 

Molecular Prosthetics: Replicating the Functions of the Molecules of Life.
Burke, M. D.
ACS Enhancing Chemistry Conference, University of Illinois, Urbana, IL, March 17, 2006.

Blocc Chemistry

Bonding carbons iteratively.
Martin D. Burke
Science 393, 763-764(2026).
https://doi.org/10.1126/science.aeg5569

Green, N. M.; Hammond, R. I.; Planey, J.; Angello, N. H.; Putnam, J. L. B.; Berry, M.; He, W.; Chen, E.; Nuñez-Corrales, S.; Loving, D. C.; Wang, W.; Huang, T.; Gunasekera, B.; Marville, K.; Switzky, R.; Desmond, S.; Burke, M. D.
Illuminating the Interface of Blocc Chemistry and Data Science: Maximizing Function with ML-Guided Discovery and a Digital Molecule Maker.
J. Chem. Educ. 2025, ASAP. https://doi.org/10.1021/acs.jchemed.5c00795.

Green, N. M.; Putnam, J. L. B.; Hammond, R. I.; Angello, N. H.; Planey, J.; Brandt, D.; Andino Martinez, J.; Hummel, T.; Gunasekera, B.; Switzky, R.; Desmond, S.; Burke, M. D.
Illuminating the Interface of Blocc Chemistry and Data Science: An Introduction to K-Nearest Neighbor Analysis and K-Medoids Clustering.
J. Chem. Educ. 2025, 102 (12), 5273–5281. https://doi.org/10.1021/acs.jchemed.5c00796.

Edwards, C.; Han, C.; Lee, G.; Nguyen, T.; Szymkuć, S.; Prasad, C. K.; Jin, B.; Han, J.; Diao, Y.; Liu, G.; Peng, H.; Grzybowski, B. A.; Burke, M. D.; Ji, H.
mCLM: A Modular Chemical Language Model that Generates Functional and Makeable Molecules.
arXiv 2025, arXiv:2505.12565. https://doi.org/10.48550/arXiv.2505.12565.

Nguyen, T.; Huang, K.; Liu, G.; Burke, M. D.; Diao, Y.; Ji, H.
FARM: Functional Group-Aware Representations for Small Molecules.
arXiv 2025, arXiv:2410.02082v3. https://doi.org/10.48550/arXiv.2410.02082.

Martin D. Burke, Scott E. Denmark, Ying Diao, Jiawei Han, Rachel Switzky, and Huimin Zhao
Molecule Maker Lab Institute: Accelerating, Advancing, and Democratizing Molecular Innovation.
AI Mag. 2025, 45 (1), 117–123. https://doi.org/10.1002/aaai.12154.

Angello, N. H.; Friday, D. M.; Hwang, C.; Yi, S.; Cheng, A. H.; Torres-Flores, T. C.; Jira, E. R.; Wang, W.; Aspuru-Guzik, A.; Burke, M. D.; Schroeder, C. M.; Diao, Y.; Jackson, N. E.
Closed-Loop Transfer Enables Artificial Intelligence to Yield Chemical Knowledge.
Nature 2024, 633, 351–358. https://doi.org/10.1038/s41586-024-07892-1.

Wang, W.; Angello, N. H.; Blair, D. J.; Tyrikos-Ergas, T.; Krueger, W. H.; Medine, K. N. S.; LaPorte, A. J.; Berger, J. M.; Burke, M. D.
Rapid Automated Iterative Small-Molecule Synthesis.
Nat. Synth. 2024, 3, 1061. https://doi.org/10.1038/s44160-024-00601-w.

Strieth-Kalthoff, F.; Hao, H.; Rathore, V.; Derasp, J.; Gaudin, T.; Angello, N. H.; et al.; Burke, M. D.; Aspuru-Guzik, A.
Delocalized, Asynchronous, Closed-Loop Discovery of Organic Laser Emitters.
Science 2024, 384, eadk9227. https://doi.org/10.1126/science.adk9227.

Klucznik, T.; Syntrivanis, L. D.; Baś, S.; Mikulak-KluczniK, B.; Moskal, M.; Szymkuć, S.; Mlynarski, J.; Beker, W.; Burke, M. D.; Tiefenbacher, K.; Grzybowski, B. A.
Computational Prediction of Complex Cationic Rearrangement Outcomes.
Nature 2024, 625, 508–515. https://doi.org/10.1038/s41586-023-06854-3.

LaPorte, A. J.; Feldner, J. E.; Spies, J. C.; Maher, T. J.; Burke, M. D.
MIDA- and TIDA-Boronates Stabilize α-Radicals Through B−N Hyperconjugation.
Angew. Chem., Int. Ed. 2023, 62, e202309566. https://doi.org/10.1002/anie.202309566.

Wu, T. C.; Granda, A. A.; Hotta, K.; Yazdani, S. A.; Pollice, R.; Vestfrid, J.; et al.; Burke, M. D.; Adachi, C.; Aspuru-Guzik, A.
A Materials Acceleration Platform for Organic Laser Discovery.
Adv. Mater. 2023, 35 (6), 2207070. https://doi.org/10.1002/adma.202207070.

Angello, N. H.; Rathore, V.; Beker, W.; Wołos, A.; Jira, E. R.; Roszak, R.; Wu, T. C.; Schroeder, C. M.; Aspuru-Guzik, A.; Grzybowski, B. A.; Burke, M. D.
Closed-Loop Optimization of General Reaction Conditions for Heteroaryl Suzuki–Miyaura Coupling.
Science 2022, 378, 399–405. https://doi.org/10.1126/science.adc8743.

LaPorte, A. J.; Shi, Y.; Hein, J. E.; Burke, M. D.
Stereospecific Csp³ Suzuki–Miyaura Cross-Coupling That Evades β-Oxygen Elimination.
ACS Catal. 2022, 12, 10905–10912. https://doi.org/10.1021/acscatal.2c03245.

Bubliauskas, A.; Blair, D. J.; Powell-Davies, H.; Kitson, P. J.; Burke, M. D.; Cronin, L.
Digitizing Chemical Synthesis in 3D-Printed Reactionware.
Angew. Chem., Int. Ed. 2022, e202116108. https://doi.org/10.1002/anie.202116108.

Chen, P. J.; Kelly, A. M.; Blair, D. J.; Burke, M. D.
Preparation of MIDA Anhydride and Reaction with Boronic Acids.
Org. Synth. 2022, 99, 92–112. https://doi.org/10.15227/orgsyn.099.0092.

Li, S.; Jira, E. R.; Angello, N. H.; Li, J.; Yu, H.; Moore, J. S.; Diao, Y.; Burke, M. D.; Schroeder, C. M.
Using Automated Synthesis to Understand the Role of Side Chains on Molecular Charge Transport.
Nat. Commun. 2022, 13, 2102. https://doi.org/10.1038/s41467-022-29796-2.

Blair, D. J.; Chitti, S.; Trobe, M.; Kostyra, D. M.; Haley, H. M. S.; Hansen, R. L.; et al.; Burke, M. D.
Automated Iterative Csp³–C Bond Formation.
Nature 2022, 604, 92–97. https://doi.org/10.1038/s41586-022-04491-w.

Burke, M. D.
Machine Learning May Sometimes Simply Capture Literature Popularity Trends: A Case Study of Heterocyclic Suzuki–Miyaura Coupling.
J. Am. Chem. Soc. 2022, 144, 4819–4827. https://doi.org/10.1021/jacs.1c12005.

Wang, H.; Li, W.; Jin, X.; Cho, K.; Ji, H.; Han, J.; Burke, M. D.
Chemical-Reaction-Aware Molecule Representation Learning.
arXiv 2021, arXiv:2109.09888. https://doi.org/10.48550/arXiv.2109.09888.

Li, S.; Yu, H.; Li, J.; Angello, N.; Jira, E. R.; Li, B.; Burke, M. D.; Moore, J. S.; Schroeder, C. M.
Transition Between Nonresonant and Resonant Charge Transport in Molecular Junctions.
Nano Lett. 2021, 21 (19), 8340–8347. https://doi.org/10.1021/acs.nanolett.1c02915.

Kelly, A. M.; Chen, P. J.; Klubnick, J.; Blair, D. J.; Burke, M. D.
A Mild Method for Making MIDA Boronates.
Org. Lett. 2020, 22 (24), 9408–9414. https://doi.org/10.1021/acs.orglett.0c02449.

Jo, Y. I.; Burke, M. D.; Cheon, C. H.
Modular Syntheses of Phenanthroindolizidine Natural Products.
Org. Lett. 2019, 21 (11), 4201–4204. https://doi.org/10.1021/acs.orglett.9b01397.

Lehmann, J. W.; Crouch, I. T.; Blair, D. J.; Trobe, M.; Wang, P.; Li, J.; Burke, M. D.
Axial Shielding of Pd(II) Complexes Enables Perfect Stereoretention in Suzuki–Miyaura Cross-Coupling of Csp³ Boronic Acids.
Nat. Commun. 2019, 10, 1263. https://doi.org/10.1038/s41467-019-09249-z.

Haley, H. M. S.; Hill, A. G.; Greenwood, A. I.; Woerly, E. M.; Rienstra, C. M.; Burke, M. D.
Peridinin Is an Exceptionally Potent and Membrane-Embedded Inhibitor of Bilayer Lipid Peroxidation.
J. Am. Chem. Soc. 2018, 140 (45), 15227–15240. https://doi.org/10.1021/jacs.8b06933.

Trobe, M.; Burke, M. D.
The Molecular Industrial Revolution: Automated Synthesis of Small Molecules.
Angew. Chem., Int. Ed. 2018, 57, 4192–4214. https://doi.org/10.1002/anie.201710482.

Lehmann, J. W.; Blair, D. J.; Burke, M. D.
Towards the Generalized Iterative Synthesis of Small Molecules.
Nat. Rev. Chem. 2018, 2, 0115. https://doi.org/10.1038/s41570-018-0115.

Palazzolo, A. M. E.; Simons, C. L. W.; Burke, M. D.
The Natural Productome.
Proc. Natl. Acad. Sci. U.S.A. 2017, 114 (22), 5564–5566. https://doi.org/10.1073/pnas.1706266114.

Gonzalez, J. A.; Ogba, O. M.; Morehouse, G. F.; Rosson, N.; Houk, K. N.; Leach, A. G.; Cheong, P. H. Y.; Burke, M. D.; Lloyd-Jones, G. C.
MIDA Boronates Are Hydrolyzed Fast and Slow by Two Different Mechanisms.
Nat. Chem. 2016, 8, 1067–1075. https://doi.org/10.1038/nchem.2571.

Endo, M. M.; Cioffi, A. G.; Burke, M. D.
Our Path to Less Toxic Amphotericins.
Synlett 2015, 27, 337. https://doi.org/10.1055/s-0035-1560800.

Li, J.; Grillo, A. S.; Burke, M. D.
From Synthesis to Function via Iterative Assembly of N-Methyliminodiacetic Acid Boronate Building Blocks.
Acc. Chem. Res. 2015, 48 (8), 2297–2307. https://doi.org/10.1021/acs.accounts.5b00128.

Burke, M. D.; Wang, P.; Crouch, I.
Cross-Coupling of Unactivated Secondary Boronic Acids.
U.S. Patent 61/899,296, filed Nov 3, 2013.

Li, J.; Ballmer, S. G.; Gillis, E. P.; Fujii, S.; Schmidt, M. J.; Palazzolo, A. M. E.; Lehmann, J. W.; Morehouse, G. F.; Burke, M. D.
Synthesis of Many Different Types of Organic Small Molecules Using One Automated Process.
Science 2015, 347, 1221–1226. https://doi.org/10.1126/science.aaa5414.

Woerly, E. M.; Roy, J.; Burke, M. D.
Synthesis of Most Polyene Natural Product Motifs Using Just Twelve Building Blocks and One Coupling Reaction.
Nat. Chem. 2014, 6, 484–491. https://doi.org/10.1038/nchem.1947.

Woerly, E. M.; Miller, J. E.; Burke, M. D.
(1-Bromovinyl)-MIDA Boronate: A Readily Accessible and Highly Versatile Building Block for Small Molecule Synthesis.
Tetrahedron 2013, 69, 7732–7740. https://doi.org/10.1016/j.tet.2013.05.050.

Gray, K. C.; Palacios, D. S.; Dailey, I.; Endo, M. M.; Uno, B. E.; Wilcock, B. C.; Burke, M. D.
Amphotericin Primarily Kills Yeast by Simply Binding Ergosterol.
Proc. Natl. Acad. Sci. U.S.A. 2012, 109, 2234–2239. https://doi.org/10.1073/pnas.1117280109.

Dick, G. R.; Woerly, E. M.; Burke, M. D.
A General Solution for the 2-Pyridyl Problem.
Angew. Chem., Int. Ed. 2012, 51 (11), 2667–2672. https://doi.org/10.1002/anie.201108608.

Li, J.; Burke, M. D.
Pinene-Derived Iminodiacetic Acid (PIDA): A Powerful Ligand for Stereoselective Synthesis and Iterative Cross-Coupling of C(sp³) Boronate Building Blocks.
J. Am. Chem. Soc. 2011, 133 (35), 13774–13777. https://doi.org/10.1021/ja205912y.

Woerly, E. M.; Struble, J. R.; Palyam, N.; O’Hara, S. P.; Burke, M. D.
(Z)-(2-Bromovinyl)-MIDA Boronate: A Readily Accessible and Highly Versatile Building Block for Small Molecule Synthesis.
Tetrahedron 2011, 67 (24), 4333–4343. https://doi.org/10.1016/j.tet.2011.04.021.

Fujii, S.; Chang, S. Y.; Burke, M. D.
Total Synthesis of Synechoxanthin through Iterative Cross-Coupling.
Angew. Chem., Int. Ed. 2011, 50 (34), 7862–7864. https://doi.org/10.1002/anie.201102688.

Lee, S. J.; Anderson, T. M.; Burke, M. D.
A Simple and General Platform for Generating Stereochemically Complex Polyene Frameworks by Iterative Cross-Coupling.
Angew. Chem., Int. Ed. 2010, 49 (47), 8860–8863. https://doi.org/10.1002/anie.201004911.

Struble, J. R.; Lee, S. J.; Burke, M. D.
Ethynyl MIDA Boronate: A Readily Accessible and Highly Versatile Building Block for Small Molecule Synthesis.
Tetrahedron 2010, 66 (26), 4710–4718. https://doi.org/10.1016/j.tet.2010.04.020.

Dick, G. R.; Knapp, D. M.; Gillis, E. P.; Burke, M. D.
General Method for Synthesis of 2-Heterocyclic N-Methyliminodiacetic Acid Boronates.
Org. Lett. 2010, 12 (10), 2314–2317. https://doi.org/10.1021/ol100671v.

Knapp, D. M.; Gillis, E. P.; Burke, M. D.
A General Solution for Unstable Boronic Acids: Slow-Release Cross-Coupling from Air-Stable MIDA Boronates.
J. Am. Chem. Soc. 2009, 131 (20), 6961–6963. https://doi.org/10.1021/ja901416p.

Uno, B. E.; Gillis, E. P.; Burke, M. D.
Vinyl MIDA Boronate: A Readily Accessible and Highly Versatile Building Block for Small Molecule Synthesis.
Tetrahedron 2009, 65 (16), 3130–3138. https://doi.org/10.1016/j.tet.2008.11.010.

Ballmer, S. G.; Gillis, E. P.; Burke, M. D.; Morton, D.; Davies, H. M. L.
B-Protected Haloboronic Acids for Iterative Cross-Coupling.
Org. Synth. 2009, 86, 344–359. https://doi.org/10.1002/0471264229.os086.33.

Gillis, E. P.; Burke, M. D.
Iterative Cross-Coupling with MIDA Boronates: Towards a General Strategy for Small-Molecule Synthesis.
Aldrichimica Acta 2009, 42 (1), 17–27.

Gillis, E. P.; Burke, M. D.
Multistep Synthesis of Complex Boronic Acids from Simple MIDA Boronates.
J. Am. Chem. Soc. 2008, 130 (43), 14084–14085. https://doi.org/10.1021/ja8063759.

Lee, S. J.; Gray, K. C.; Paek, J. S.; Burke, M. D.
Simple, Efficient, and Modular Syntheses of Polyene Natural Products via Iterative Cross-Coupling.
J. Am. Chem. Soc. 2008, 130 (2), 466–468. https://doi.org/10.1021/ja078129x.

Gillis, E. P.; Burke, M. D.
A Simple and Modular Strategy for Small Molecule Synthesis: Iterative Suzuki–Miyaura Coupling of B-Protected Haloboronic Acid Building Blocks.
J. Am. Chem. Soc. 2007, 129 (21), 6716–6717. https://doi.org/10.1021/ja0716204.

Molecular Prosthetics

Marin-Toledo, J. P.; Greenan, D. M.; Celis, N.; Haske, L.; Lewandowska, A.; Maji, A.; Green, K. J.; Rakowski, C. K.; Shastry, S.; Maji, A.; Welsh, M. J.; Thornell, I. M.; Burke, M. D.
Molecular Prosthetics for CFTR Designed for Anion Selectivity Outperform Amphotericin B in Cultured Cystic Fibrosis Airway Epithelia.
bioRxiv 2025, 2025.08.28.671923. https://doi.org/10.1101/2025.08.28.671923.

Celis, N.; Miller, D. P.; Tarara, T. E.; Weers, J. G.; Thornell, I. M.; Welsh, M. J.; Burke, M. D.
Molecular Prosthetics and CFTR Modulators Additively Increase Secretory HCO₃⁻ Flux in Cystic Fibrosis Airway Epithelia.
bioRxiv 2025, 2025.06.18.660463. https://doi.org/10.1101/2025.06.18.660463.

Blake, A. D.; Chao, J.; SantaMaria, A. M.; Ekaputri, S.; Green, K. J.; Brown, S. T.; Rakowski, C. K.; Choi, E.; Aring, L.; Chen, P.; Snead, N. M.; Matje, D. M.; et al.; Burke, M. D.
Minimizing Higher-Order Aggregation Maximizes Iron Mobilization by Small Molecules.
Nat. Chem. Biol. 2024, 20, 1282–1293. https://doi.org/10.1038/s41589-024-01596-3.

Weers, J.; Reisner, C.; St. Rose, E.; Pelc, C.; Tompkins, D.; Desai, D.; Pavlov, A.; Salinas, T.; Moll, P.; Sellwood, C.; Eldon, M.; Strader, C.; Welsh, M. J.; Burke, M. D.
Inhaled Amphotericin Shows Good Safety and Tolerability in Phase 1 Studies in Healthy Subjects.
J. Cyst. Fibros. 2024, 23, S152–S153. https://doi.org/10.1016/S1569-1993(24)01126-3.

Celis, N.; Miller, D.; Tarara, T.; Weers, J.; Burke, M. D.
Molecular Prosthetics and CFTR Modulators Additively Increase Host Defenses in Cystic Fibrosis Airway Epithelia.
J. Cyst. Fibros. 2024, 23, S161. https://doi.org/10.1021/acschembio.5c00473.

Marin-Toledo, J. P.; Greenan, D. M.; Thornell, I. M.; Celis, N.; Haske, L.; Lewandowska, A.; Maji, A.; Green, K. J.; Welsh, M. J.; Burke, M. D.
Anion-Selective Molecular Prosthetics for CFTR Outperform Amphotericin B in Cultured CF Epithelia.
J. Cyst. Fibros. 2024, 23, S156. https://doi.org/10.1016/S1569-1993(24)01133-0.

Maji, A.; Soutar, C. P.; Zhang, J.; Lewandowska, A.; Uno, B. E.; Yan, S.; Shelke, Y.; Murhade, G.; Nimerovsky, E.; Borcik, C. G.; et al.; Burke, M. D.
Tuning Sterol Extraction Kinetics Yields a Renal-Sparing Polyene Antifungal.
Nature 2023, 623, 1079–1085. https://doi.org/10.1038/s41586-023-06710-4.

Burke, M. D.; Welsh, M. J.; Weers, J.; Sellwood, C.; Reisner, C.
Amphotericin B Cystetic for Inhalation (CM001): A Randomized, Double-Blind Study in Healthy Volunteers.
J. Cyst. Fibros. 2023, 22, S129. https://doi.org/10.1016/S1569-1993(23)01183-9.

Ripa, L. A. D.; Courtney, J. M.; Phinney, S. M.; Borcik, C. G.; Burke, M. D.; Rienstra, C. M.; Pogorelov, T. V.
Segmental Dynamics of Membranous Cholesterol Are Coupled.
J. Am. Chem. Soc. 2023, 145, 15043–15048. https://doi.org/10.1021/jacs.3c01775.

Lewandowska, A.; Thornell, I. M.; Soutar, C.; Green, K. J.; Marin-Toledo, J. P.; Shelke, Y.; Miller, D.; Tarara, T.; Pogorelov, T. V.; Rienstra, C.; Welsh, M. J.; Weers, J.; Burke, M. D.
Understanding the Role of Cholesterol in Optimizing Molecular Prosthetics for Cystic Fibrosis.
J. Cyst. Fibros. 2023, 22, S142–S143. https://doi.org/10.1016/S1569-1993(23)01210-9.

Lewandowska, A.; Thornell, I. M.; Soutar, C. P.; Green, K. J.; Lange, J.; Miller, D.; Tarara, T.; Pogorelov, T. V.; Rienstra, C.; Welsh, M. J.; Weers, J.; Burke, M. D.
A Rationally Designed Molecular Prosthetic for Cystic Fibrosis.
J. Cyst. Fibros. 2022, 21, S337. https://doi.org/10.1016/S1569-1993(22)01297-8.

Miller, D.; Tarara, T.; Lyons, S.; Burke, M. D.; Lewandowska, A.; Soutar, C. P.; Weers, J.
A Dry Powder Aerosol Comprising a Small-Molecule Prosthetic Ion Channel for Cystic Fibrosis.
J. Cyst. Fibros. 2022, 21, S229. https://doi.org/10.1016/s1569-1993(22)01082-7.

Ekaputri, S.; Choi, E.; Sabelli, M.; Aring, L.; Green, K. J.; Chang, J.; Bao, K.; Choi, H. S.; Iwase, S.; Kim, J.; Corradini, E.; Pietrangelo, A.; Burke, M. D.; Seo, Y. A.
A Small Molecule Redistributes Iron in Ferroportin-Deficient Models.
Proc. Natl. Acad. Sci. U.S.A. 2022, 119, e2121400119. https://doi.org/10.1073/pnas.2121400119.

Lewandowska, A.; Soutar, C. P.; Greenwood, A. I.; Nimerovsky, E.; De Lio, A. M.; Holler, J. T.; Hisao, G. S.; Khandelwal, A.; Zhang, J.; SantaMaria, A. M.; Schwieters, C. D.; Pogorelov, T. V.; Burke, M. D.; Rienstra, C. M.
Fungicidal amphotericin B sponges are assemblies of staggered asymmetric homodimers encasing large void volumes.
Nat. Struct. Mol. Biol. 2021, 12, 972–981. https://doi.org/10.1038/s41594-021-00685-4.

Guo, X.; Zhang, J.; Li, X.; Xiao, E.; Lange, J. D.; Rienstra, C. M.; Burke, M. D.; Mitchell, D. A.
Sterol Sponge Mechanism Is Conserved for Glycosylated Polyene Macrolides.
ACS Cent. Sci. 2021, 7, 781–791. https://doi.org/10.1021/acscentsci.1c00148.

Chorghade, R. S.; Kim, B. R.; Launspach, J. L.; Karp, P. H.; Welsh, M. J.; Burke, M. D.
Amphotericin B Induces Epithelial Voltage Responses in People with Cystic Fibrosis.
J. Cyst. Fibros. 2020, 7, 781–791. https://doi.org/10.1016/j.jcf.2020.11.018.

Hou, J.; Daniels, P. N.; Burke, M. D.
Small Molecule Channels Harness Membrane Potential to Concentrate Potassium in Yeast.
ACS Chem. Biol. 2020, 15, 1575–1580. https://doi.org/10.1021/acschembio.0c00180.

Muraglia, K. A.; Chorghade, R. S.; Kim, B. R.; Tang, X. X.; Shah, V. S.; Grillo, A. S.; Daniels, P. N.; Cioffi, A. G.; Karp, P. H.; Zhu, L.; Welsh, M. J.; Burke, M. D.
Small-Molecule Ion Channels Increase Host Defenses in Cystic Fibrosis Airway Epithelia.
Nature 2019, 567, 405–408. https://doi.org/10.1038/s41586-019-1018-5.

Yien, Y. Y.; Shi, J.; Chen, C.; Cheung, J. T. M.; etc.; Burke, M. D.; Paw, B. H.
FAM210B Regulates Erythroid Heme Synthesis via Mitochondrial Iron Import.
J. Biol. Chem. 2018, 293, 19797–19811. https://doi.org/10.1074/jbc.RA118.002742.

Yien, Y. Y.; Shi, J.; Chen, C.; Cheung, J. T. M.; etc.; Burke, M. D.; Paw, B. H.
Target of Erythropoietin, FAM210B, Regulates Erythroid Heme Synthesis.
Blood 2018, 132, 849. https://doi.org/10.1182/blood-2018-99-120299.

Haley, H. M. S.; Hill, A. G.; Greenwood, A. I.; Woerly, E. M.; Rienstra, C. M.; Burke, M. D.
Peridinin Is an Exceptionally Potent and Membrane-Embedded Inhibitor of Bilayer Lipid Peroxidation.
J. Am. Chem. Soc. 2018, 140, 15227–15240. https://doi.org/10.1021/jacs.8b06933.

Ripa, L. A. D.; Petros, Z. A.; Cioffi, A. G.; Piehl, D. W.; Courtney, J. M.; Burke, M. D.; Rienstra, C. M.
Solid-State NMR of Highly 13C-Enriched Cholesterol in Lipid Bilayers.
Methods 2018, 138–139, 47–53. https://doi.org/10.1016/j.ymeth.2018.01.008.

Grillo, A. S.; SantaMaria, A. M.; Kafina, M. D.; Cioffi, A. G.; etc.; Burke, M. D.
Restored Iron Transport by a Small Molecule Promotes Absorption and Hemoglobinization in Animals.
Science 2017, 356, 608–615. https://doi.org/10.1126/science.aah3862.

Endo, M. M.; Cioffi, A. G.; Burke, M. D.
Our Path to Less Toxic Amphotericins.
Synlett 2015, 27, 337. https://doi.org/10.1055/s-0035-1560800.

Davis, S. A.; Ripa, L. A. D.; Hu, L.; Cioffi, A. G.; Pogorelov, T. V.; Rienstra, C. M.; Burke, M. D.
C3-OH of Amphotericin B Plays an Important Role in Ion Conductance.
J. Am. Chem. Soc. 2015, 137, 15102–15104. https://doi.org/10.1021/jacs.5b05766.

Cioffi, A. G.; Hou, J.; Grillo, A. S.; Diaz, K. A.; Burke, M. D.
Restored Physiology in Protein-Deficient Yeast by a Small Molecule Channel.
J. Am. Chem. Soc. 2015, 137, 10096–10099. https://doi.org/10.1021/jacs.5b05765.

Anderson, T. M.; Clay, M. C.; Cioffi, A. G.; Diaz, K. A.; Hisao, G. S.; Tuttle, M. D.; etc.; Burke, M. D.
Amphotericin Forms an Extramembranous and Fungicidal Sterol Sponge.
Nat. Chem. Biol. 2014, 10, 400–406. https://doi.org/10.1038/nchembio.1496.

Wilcock, B. C.; Endo, M. M.; Uno, B. E.; Burke, M. D.
C2′-OH of Amphotericin B Plays an Important Role in Binding the Primary Sterol of Human Cells but Not Yeast Cells.
J. Am. Chem. Soc. 2013, 135, 8488–8491. https://doi.org/10.1021/ja403255s.

Gray, K. C.; Palacios, D. S.; Dailey, I.; Endo, M. M.; Uno, B. E.; Wilcock, B. C.; Burke, M. D.
Amphotericin Primarily Kills Yeast by Simply Binding Ergosterol.
Proc. Natl. Acad. Sci. U.S.A. 2012, 109, 2234–223. https://doi.org/10.1073/pnas.1117280109.