Publications

Browse our peer-reviewed publications.

The following is a representative selection.
For a comprehensive list, visit Google Scholar.

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Blocc Chemistry

Green, N. M.; Hammond, R. I.; Planey, J.; Angello, N. H.; Putnam, J. L. B.; Berry, M.; He, W.; Chen, E.; Nuñez-Corrales, S.; Loving, D. C.; Wang, W.; Huang, T.; Gunasekera, B.; Marville, K.; Switzky, R.; Desmond, S.; Burke, M. D.
Illuminating the Interface of Blocc Chemistry and Data Science: Maximizing Function with ML-Guided Discovery and a Digital Molecule Maker.
J. Chem. Educ. 2025, ASAP. https://doi.org/10.1021/acs.jchemed.5c00795.

Green, N. M.; Putnam, J. L. B.; Hammond, R. I.; Angello, N. H.; Planey, J.; Brandt, D.; Andino Martinez, J.; Hummel, T.; Gunasekera, B.; Switzky, R.; Desmond, S.; Burke, M. D.
Illuminating the Interface of Blocc Chemistry and Data Science: An Introduction to K-Nearest Neighbor Analysis and K-Medoids Clustering.
J. Chem. Educ. 2025, 102 (12), 5273–5281. https://doi.org/10.1021/acs.jchemed.5c00796.

Edwards, C.; Han, C.; Lee, G.; Nguyen, T.; Szymkuć, S.; Prasad, C. K.; Jin, B.; Han, J.; Diao, Y.; Liu, G.; Peng, H.; Grzybowski, B. A.; Burke, M. D.; Ji, H.
mCLM: A Modular Chemical Language Model that Generates Functional and Makeable Molecules.
arXiv 2025, arXiv:2505.12565. https://doi.org/10.48550/arXiv.2505.12565.

Nguyen, T.; Huang, K.; Liu, G.; Burke, M. D.; Diao, Y.; Ji, H.
FARM: Functional Group-Aware Representations for Small Molecules.
arXiv 2025, arXiv:2410.02082v3. https://doi.org/10.48550/arXiv.2410.02082.

Martin D. Burke, Scott E. Denmark, Ying Diao, Jiawei Han, Rachel Switzky, and Huimin Zhao
Molecule Maker Lab Institute: Accelerating, Advancing, and Democratizing Molecular Innovation.
AI Mag. 2025, 45 (1), 117–123. https://doi.org/10.1002/aaai.12154.

Angello, N. H.; Friday, D. M.; Hwang, C.; Yi, S.; Cheng, A. H.; Torres-Flores, T. C.; Jira, E. R.; Wang, W.; Aspuru-Guzik, A.; Burke, M. D.; Schroeder, C. M.; Diao, Y.; Jackson, N. E.
Closed-Loop Transfer Enables Artificial Intelligence to Yield Chemical Knowledge.
Nature 2024, 633, 351–358. https://doi.org/10.1038/s41586-024-07892-1.

Wang, W.; Angello, N. H.; Blair, D. J.; Tyrikos-Ergas, T.; Krueger, W. H.; Medine, K. N. S.; LaPorte, A. J.; Berger, J. M.; Burke, M. D.
Rapid Automated Iterative Small-Molecule Synthesis.
Nat. Synth. 2024, 3, 1061. https://doi.org/10.1038/s44160-024-00601-w.

Strieth-Kalthoff, F.; Hao, H.; Rathore, V.; Derasp, J.; Gaudin, T.; Angello, N. H.; et al.; Burke, M. D.; Aspuru-Guzik, A.
Delocalized, Asynchronous, Closed-Loop Discovery of Organic Laser Emitters.
Science 2024, 384, eadk9227. https://doi.org/10.1126/science.adk9227.

Klucznik, T.; Syntrivanis, L. D.; Baś, S.; Mikulak-KluczniK, B.; Moskal, M.; Szymkuć, S.; Mlynarski, J.; Beker, W.; Burke, M. D.; Tiefenbacher, K.; Grzybowski, B. A.
Computational Prediction of Complex Cationic Rearrangement Outcomes.
Nature 2024, 625, 508–515. https://doi.org/10.1038/s41586-023-06854-3.

LaPorte, A. J.; Feldner, J. E.; Spies, J. C.; Maher, T. J.; Burke, M. D.
MIDA- and TIDA-Boronates Stabilize α-Radicals Through B−N Hyperconjugation.
Angew. Chem., Int. Ed. 2023, 62, e202309566. https://doi.org/10.1002/anie.202309566.

Wu, T. C.; Granda, A. A.; Hotta, K.; Yazdani, S. A.; Pollice, R.; Vestfrid, J.; et al.; Burke, M. D.; Adachi, C.; Aspuru-Guzik, A.
A Materials Acceleration Platform for Organic Laser Discovery.
Adv. Mater. 2023, 35 (6), 2207070. https://doi.org/10.1002/adma.202207070.

Angello, N. H.; Rathore, V.; Beker, W.; Wołos, A.; Jira, E. R.; Roszak, R.; Wu, T. C.; Schroeder, C. M.; Aspuru-Guzik, A.; Grzybowski, B. A.; Burke, M. D.
Closed-Loop Optimization of General Reaction Conditions for Heteroaryl Suzuki–Miyaura Coupling.
Science 2022, 378, 399–405. https://doi.org/10.1126/science.adc8743.

LaPorte, A. J.; Shi, Y.; Hein, J. E.; Burke, M. D.
Stereospecific Csp³ Suzuki–Miyaura Cross-Coupling That Evades β-Oxygen Elimination.
ACS Catal. 2022, 12, 10905–10912. https://doi.org/10.1021/acscatal.2c03245.

Bubliauskas, A.; Blair, D. J.; Powell-Davies, H.; Kitson, P. J.; Burke, M. D.; Cronin, L.
Digitizing Chemical Synthesis in 3D-Printed Reactionware.
Angew. Chem., Int. Ed. 2022, e202116108. https://doi.org/10.1002/anie.202116108.

Chen, P. J.; Kelly, A. M.; Blair, D. J.; Burke, M. D.
Preparation of MIDA Anhydride and Reaction with Boronic Acids.
Org. Synth. 2022, 99, 92–112. https://doi.org/10.15227/orgsyn.099.0092.

Li, S.; Jira, E. R.; Angello, N. H.; Li, J.; Yu, H.; Moore, J. S.; Diao, Y.; Burke, M. D.; Schroeder, C. M.
Using Automated Synthesis to Understand the Role of Side Chains on Molecular Charge Transport.
Nat. Commun. 2022, 13, 2102. https://doi.org/10.1038/s41467-022-29796-2.

Blair, D. J.; Chitti, S.; Trobe, M.; Kostyra, D. M.; Haley, H. M. S.; Hansen, R. L.; et al.; Burke, M. D.
Automated Iterative Csp³–C Bond Formation.
Nature 2022, 604, 92–97. https://doi.org/10.1038/s41586-022-04491-w.

Burke, M. D.
National Center for Automated Chemical Synthesis and Democratized Molecular Innovation (ACSDMI).
NSF Award 2223127, Directorate for Mathematical and Physical Sciences, 2022.

Beker, W.; Roszak, R.; Wołos, A.; Angello, N. H.; Rathore, V.; Burke, M. D.; Grzybowski, B. A.
Machine Learning May Sometimes Simply Capture Literature Popularity Trends: A Case Study of Heterocyclic Suzuki–Miyaura Coupling.
J. Am. Chem. Soc. 2022, 144, 4819–4827. https://doi.org/10.1021/jacs.1c12005.

Wang, H.; Li, W.; Jin, X.; Cho, K.; Ji, H.; Han, J.; Burke, M. D.
Chemical-Reaction-Aware Molecule Representation Learning.
arXiv 2021, arXiv:2109.09888. https://doi.org/10.48550/arXiv.2109.09888.

Li, S.; Yu, H.; Li, J.; Angello, N.; Jira, E. R.; Li, B.; Burke, M. D.; Moore, J. S.; Schroeder, C. M.
Transition Between Nonresonant and Resonant Charge Transport in Molecular Junctions.
Nano Lett. 2021, 21 (19), 8340–8347. https://doi.org/10.1021/acs.nanolett.1c02915.

Kelly, A. M.; Chen, P. J.; Klubnick, J.; Blair, D. J.; Burke, M. D.
A Mild Method for Making MIDA Boronates.
Org. Lett. 2020, 22 (24), 9408–9414. https://doi.org/10.1021/acs.orglett.0c02449.

Jo, Y. I.; Burke, M. D.; Cheon, C. H.
Modular Syntheses of Phenanthroindolizidine Natural Products.
Org. Lett. 2019, 21 (11), 4201–4204. https://doi.org/10.1021/acs.orglett.9b01397.

Lehmann, J. W.; Crouch, I. T.; Blair, D. J.; Trobe, M.; Wang, P.; Li, J.; Burke, M. D.
Axial Shielding of Pd(II) Complexes Enables Perfect Stereoretention in Suzuki–Miyaura Cross-Coupling of Csp³ Boronic Acids.
Nat. Commun. 2019, 10, 1263. https://doi.org/10.1038/s41467-019-09249-z.

Haley, H. M. S.; Hill, A. G.; Greenwood, A. I.; Woerly, E. M.; Rienstra, C. M.; Burke, M. D.
Peridinin Is an Exceptionally Potent and Membrane-Embedded Inhibitor of Bilayer Lipid Peroxidation.
J. Am. Chem. Soc. 2018, 140 (45), 15227–15240. https://doi.org/10.1021/jacs.8b06933.

Trobe, M.; Burke, M. D.
The Molecular Industrial Revolution: Automated Synthesis of Small Molecules.
Angew. Chem., Int. Ed. 2018, 57, 4192–4214. https://doi.org/10.1002/anie.201710482.

Lehmann, J. W.; Blair, D. J.; Burke, M. D.
Towards the Generalized Iterative Synthesis of Small Molecules.
Nat. Rev. Chem. 2018, 2, 0115. https://doi.org/10.1038/s41570-018-0115.

Palazzolo, A. M. E.; Simons, C. L. W.; Burke, M. D.
The Natural Productome.
Proc. Natl. Acad. Sci. U.S.A. 2017, 114 (22), 5564–5566. https://doi.org/10.1073/pnas.1706266114.

Gonzalez, J. A.; Ogba, O. M.; Morehouse, G. F.; Rosson, N.; Houk, K. N.; Leach, A. G.; Cheong, P. H. Y.; Burke, M. D.; Lloyd-Jones, G. C.
MIDA Boronates Are Hydrolyzed Fast and Slow by Two Different Mechanisms.
Nat. Chem. 2016, 8, 1067–1075. https://doi.org/10.1038/nchem.2571.

Endo, M. M.; Cioffi, A. G.; Burke, M. D.
Our Path to Less Toxic Amphotericins.
Synlett 2015, 27, 337. https://doi.org/10.1055/s-0035-1560800.

Li, J.; Grillo, A. S.; Burke, M. D.
From Synthesis to Function via Iterative Assembly of N-Methyliminodiacetic Acid Boronate Building Blocks.
Acc. Chem. Res. 2015, 48 (8), 2297–2307. https://doi.org/10.1021/acs.accounts.5b00128.

Burke, M. D.; Wang, P.; Crouch, I.
Cross-Coupling of Unactivated Secondary Boronic Acids.
U.S. Patent 61/899,296, filed Nov 3, 2013.

Li, J.; Ballmer, S. G.; Gillis, E. P.; Fujii, S.; Schmidt, M. J.; Palazzolo, A. M. E.; Lehmann, J. W.; Morehouse, G. F.; Burke, M. D.
Synthesis of Many Different Types of Organic Small Molecules Using One Automated Process.
Science 2015, 347, 1221–1226. https://doi.org/10.1126/science.aaa5414.

Woerly, E. M.; Roy, J.; Burke, M. D.
Synthesis of Most Polyene Natural Product Motifs Using Just Twelve Building Blocks and One Coupling Reaction.
Nat. Chem. 2014, 6, 484–491. https://doi.org/10.1038/nchem.1947.

Woerly, E. M.; Miller, J. E.; Burke, M. D.
(1-Bromovinyl)-MIDA Boronate: A Readily Accessible and Highly Versatile Building Block for Small Molecule Synthesis.
Tetrahedron 2013, 69, 7732–7740. https://doi.org/10.1016/j.tet.2013.05.050.

Gray, K. C.; Palacios, D. S.; Dailey, I.; Endo, M. M.; Uno, B. E.; Wilcock, B. C.; Burke, M. D.
Amphotericin Primarily Kills Yeast by Simply Binding Ergosterol.
Proc. Natl. Acad. Sci. U.S.A. 2012, 109, 2234–2239. https://doi.org/10.1073/pnas.1117280109.

Dick, G. R.; Woerly, E. M.; Burke, M. D.
A General Solution for the 2-Pyridyl Problem.
Angew. Chem., Int. Ed. 2012, 51 (11), 2667–2672. https://doi.org/10.1002/anie.201108608.

Li, J.; Burke, M. D.
Pinene-Derived Iminodiacetic Acid (PIDA): A Powerful Ligand for Stereoselective Synthesis and Iterative Cross-Coupling of C(sp³) Boronate Building Blocks.
J. Am. Chem. Soc. 2011, 133 (35), 13774–13777. https://doi.org/10.1021/ja205912y.

Woerly, E. M.; Struble, J. R.; Palyam, N.; O’Hara, S. P.; Burke, M. D.
(Z)-(2-Bromovinyl)-MIDA Boronate: A Readily Accessible and Highly Versatile Building Block for Small Molecule Synthesis.
Tetrahedron 2011, 67 (24), 4333–4343. https://doi.org/10.1016/j.tet.2011.04.021.

Fujii, S.; Chang, S. Y.; Burke, M. D.
Total Synthesis of Synechoxanthin through Iterative Cross-Coupling.
Angew. Chem., Int. Ed. 2011, 50 (34), 7862–7864. https://doi.org/10.1002/anie.201102688.

Lee, S. J.; Anderson, T. M.; Burke, M. D.
A Simple and General Platform for Generating Stereochemically Complex Polyene Frameworks by Iterative Cross-Coupling.
Angew. Chem., Int. Ed. 2010, 49 (47), 8860–8863. https://doi.org/10.1002/anie.201004911.

Struble, J. R.; Lee, S. J.; Burke, M. D.
Ethynyl MIDA Boronate: A Readily Accessible and Highly Versatile Building Block for Small Molecule Synthesis.
Tetrahedron 2010, 66 (26), 4710–4718. https://doi.org/10.1016/j.tet.2010.04.020.

Dick, G. R.; Knapp, D. M.; Gillis, E. P.; Burke, M. D.
General Method for Synthesis of 2-Heterocyclic N-Methyliminodiacetic Acid Boronates.
Org. Lett. 2010, 12 (10), 2314–2317. https://doi.org/10.1021/ol100671v.

Knapp, D. M.; Gillis, E. P.; Burke, M. D.
A General Solution for Unstable Boronic Acids: Slow-Release Cross-Coupling from Air-Stable MIDA Boronates.
J. Am. Chem. Soc. 2009, 131 (20), 6961–6963. https://doi.org/10.1021/ja901416p.

Uno, B. E.; Gillis, E. P.; Burke, M. D.
Vinyl MIDA Boronate: A Readily Accessible and Highly Versatile Building Block for Small Molecule Synthesis.
Tetrahedron 2009, 65 (16), 3130–3138. https://doi.org/10.1016/j.tet.2008.11.010.

Ballmer, S. G.; Gillis, E. P.; Burke, M. D.; Morton, D.; Davies, H. M. L.
B-Protected Haloboronic Acids for Iterative Cross-Coupling.
Org. Synth. 2009, 86, 344–359. https://doi.org/10.1002/0471264229.os086.33.

Gillis, E. P.; Burke, M. D.
Iterative Cross-Coupling with MIDA Boronates: Towards a General Strategy for Small-Molecule Synthesis.
Aldrichimica Acta 2009, 42 (1), 17–27.

Gillis, E. P.; Burke, M. D.
Multistep Synthesis of Complex Boronic Acids from Simple MIDA Boronates.
J. Am. Chem. Soc. 2008, 130 (43), 14084–14085. https://doi.org/10.1021/ja8063759.

Lee, S. J.; Gray, K. C.; Paek, J. S.; Burke, M. D.
Simple, Efficient, and Modular Syntheses of Polyene Natural Products via Iterative Cross-Coupling.
J. Am. Chem. Soc. 2008, 130 (2), 466–468. https://doi.org/10.1021/ja078129x.

Gillis, E. P.; Burke, M. D.
A Simple and Modular Strategy for Small Molecule Synthesis: Iterative Suzuki–Miyaura Coupling of B-Protected Haloboronic Acid Building Blocks.
J. Am. Chem. Soc. 2007, 129 (21), 6716–6717. https://doi.org/10.1021/ja0716204.

Molecular Prosthetics

Marin-Toledo, J. P.; Greenan, D. M.; Celis, N.; Haske, L.; Lewandowska, A.; Maji, A.; Green, K. J.; Rakowski, C. K.; Shastry, S.; Maji, A.; Welsh, M. J.; Thornell, I. M.; Burke, M. D.
Molecular Prosthetics for CFTR Designed for Anion Selectivity Outperform Amphotericin B in Cultured Cystic Fibrosis Airway Epithelia.
bioRxiv 2025, 2025.08.28.671923. https://doi.org/10.1101/2025.08.28.671923.

Celis, N.; Miller, D. P.; Tarara, T. E.; Weers, J. G.; Thornell, I. M.; Welsh, M. J.; Burke, M. D.
Molecular Prosthetics and CFTR Modulators Additively Increase Secretory HCO₃⁻ Flux in Cystic Fibrosis Airway Epithelia.
bioRxiv 2025, 2025.06.18.660463. https://doi.org/10.1101/2025.06.18.660463.

Blake, A. D.; Chao, J.; SantaMaria, A. M.; Ekaputri, S.; Green, K. J.; Brown, S. T.; Rakowski, C. K.; Choi, E.; Aring, L.; Chen, P.; Snead, N. M.; Matje, D. M.; et al.; Burke, M. D.
Minimizing Higher-Order Aggregation Maximizes Iron Mobilization by Small Molecules.
Nat. Chem. Biol. 2024, 20, 1282–1293. https://doi.org/10.1038/s41589-024-01596-3.

Weers, J.; Reisner, C.; St. Rose, E.; Pelc, C.; Tompkins, D.; Desai, D.; Pavlov, A.; Salinas, T.; Moll, P.; Sellwood, C.; Eldon, M.; Strader, C.; Welsh, M. J.; Burke, M. D.
Inhaled Amphotericin Shows Good Safety and Tolerability in Phase 1 Studies in Healthy Subjects.
J. Cyst. Fibros. 2024, 23, S152–S153. https://doi.org/10.1016/S1569-1993(24)01126-3.

Celis, N.; Miller, D.; Tarara, T.; Weers, J.; Burke, M. D.
Molecular Prosthetics and CFTR Modulators Additively Increase Host Defenses in Cystic Fibrosis Airway Epithelia.
J. Cyst. Fibros. 2024, 23, S161. https://doi.org/10.1021/acschembio.5c00473.

Marin-Toledo, J. P.; Greenan, D. M.; Thornell, I. M.; Celis, N.; Haske, L.; Lewandowska, A.; Maji, A.; Green, K. J.; Welsh, M. J.; Burke, M. D.
Anion-Selective Molecular Prosthetics for CFTR Outperform Amphotericin B in Cultured CF Epithelia.
J. Cyst. Fibros. 2024, 23, S156. https://doi.org/10.1016/S1569-1993(24)01133-0.

Maji, A.; Soutar, C. P.; Zhang, J.; Lewandowska, A.; Uno, B. E.; Yan, S.; Shelke, Y.; Murhade, G.; Nimerovsky, E.; Borcik, C. G.; et al.; Burke, M. D.
Tuning Sterol Extraction Kinetics Yields a Renal-Sparing Polyene Antifungal.
Nature 2023, 623, 1079–1085. https://doi.org/10.1038/s41586-023-06710-4.

Burke, M. D.; Welsh, M. J.; Weers, J.; Sellwood, C.; Reisner, C.
Amphotericin B Cystetic for Inhalation (CM001): A Randomized, Double-Blind Study in Healthy Volunteers.
J. Cyst. Fibros. 2023, 22, S129. https://doi.org/10.1016/S1569-1993(23)01183-9.

Ripa, L. A. D.; Courtney, J. M.; Phinney, S. M.; Borcik, C. G.; Burke, M. D.; Rienstra, C. M.; Pogorelov, T. V.
Segmental Dynamics of Membranous Cholesterol Are Coupled.
J. Am. Chem. Soc. 2023, 145, 15043–15048. https://doi.org/10.1021/jacs.3c01775.

Lewandowska, A.; Thornell, I. M.; Soutar, C.; Green, K. J.; Marin-Toledo, J. P.; Shelke, Y.; Miller, D.; Tarara, T.; Pogorelov, T. V.; Rienstra, C.; Welsh, M. J.; Weers, J.; Burke, M. D.
Understanding the Role of Cholesterol in Optimizing Molecular Prosthetics for Cystic Fibrosis.
J. Cyst. Fibros. 2023, 22, S142–S143. https://doi.org/10.1016/S1569-1993(23)01210-9.

Lewandowska, A.; Thornell, I. M.; Soutar, C. P.; Green, K. J.; Lange, J.; Miller, D.; Tarara, T.; Pogorelov, T. V.; Rienstra, C.; Welsh, M. J.; Weers, J.; Burke, M. D.
A Rationally Designed Molecular Prosthetic for Cystic Fibrosis.
J. Cyst. Fibros. 2022, 21, S337. https://doi.org/10.1016/S1569-1993(22)01297-8.

Miller, D.; Tarara, T.; Lyons, S.; Burke, M. D.; Lewandowska, A.; Soutar, C. P.; Weers, J.
A Dry Powder Aerosol Comprising a Small-Molecule Prosthetic Ion Channel for Cystic Fibrosis.
J. Cyst. Fibros. 2022, 21, S229. https://doi.org/10.1016/s1569-1993(22)01082-7.

Ekaputri, S.; Choi, E.; Sabelli, M.; Aring, L.; Green, K. J.; Chang, J.; Bao, K.; Choi, H. S.; Iwase, S.; Kim, J.; Corradini, E.; Pietrangelo, A.; Burke, M. D.; Seo, Y. A.
A Small Molecule Redistributes Iron in Ferroportin-Deficient Models.
Proc. Natl. Acad. Sci. U.S.A. 2022, 119, e2121400119. https://doi.org/10.1073/pnas.2121400119.

Lewandowska, A.; Soutar, C. P.; Greenwood, A. I.; Nimerovsky, E.; De Lio, A. M.; Holler, J. T.; Hisao, G. S.; Khandelwal, A.; Zhang, J.; SantaMaria, A. M.; Schwieters, C. D.; Pogorelov, T. V.; Burke, M. D.; Rienstra, C. M.
Fungicidal amphotericin B sponges are assemblies of staggered asymmetric homodimers encasing large void volumes.
Nat. Struct. Mol. Biol. 2021, 12, 972–981. https://doi.org/10.1038/s41594-021-00685-4.

Guo, X.; Zhang, J.; Li, X.; Xiao, E.; Lange, J. D.; Rienstra, C. M.; Burke, M. D.; Mitchell, D. A.
Sterol Sponge Mechanism Is Conserved for Glycosylated Polyene Macrolides.
ACS Cent. Sci. 2021, 7, 781–791. https://doi.org/10.1021/acscentsci.1c00148.

Chorghade, R. S.; Kim, B. R.; Launspach, J. L.; Karp, P. H.; Welsh, M. J.; Burke, M. D.
Amphotericin B Induces Epithelial Voltage Responses in People with Cystic Fibrosis.
J. Cyst. Fibros. 2020, 7, 781–791. https://doi.org/10.1016/j.jcf.2020.11.018.

Hou, J.; Daniels, P. N.; Burke, M. D.
Small Molecule Channels Harness Membrane Potential to Concentrate Potassium in Yeast.
ACS Chem. Biol. 2020, 15, 1575–1580. https://doi.org/10.1021/acschembio.0c00180.

Muraglia, K. A.; Chorghade, R. S.; Kim, B. R.; Tang, X. X.; Shah, V. S.; Grillo, A. S.; Daniels, P. N.; Cioffi, A. G.; Karp, P. H.; Zhu, L.; Welsh, M. J.; Burke, M. D.
Small-Molecule Ion Channels Increase Host Defenses in Cystic Fibrosis Airway Epithelia.
Nature 2019, 567, 405–408. https://doi.org/10.1038/s41586-019-1018-5.

Yien, Y. Y.; Shi, J.; Chen, C.; Cheung, J. T. M.; etc.; Burke, M. D.; Paw, B. H.
FAM210B Regulates Erythroid Heme Synthesis via Mitochondrial Iron Import.
J. Biol. Chem. 2018, 293, 19797–19811. https://doi.org/10.1074/jbc.RA118.002742.

Yien, Y. Y.; Shi, J.; Chen, C.; Cheung, J. T. M.; etc.; Burke, M. D.; Paw, B. H.
Target of Erythropoietin, FAM210B, Regulates Erythroid Heme Synthesis.
Blood 2018, 132, 849. https://doi.org/10.1182/blood-2018-99-120299.

Haley, H. M. S.; Hill, A. G.; Greenwood, A. I.; Woerly, E. M.; Rienstra, C. M.; Burke, M. D.
Peridinin Is an Exceptionally Potent and Membrane-Embedded Inhibitor of Bilayer Lipid Peroxidation.
J. Am. Chem. Soc. 2018, 140, 15227–15240. https://doi.org/10.1021/jacs.8b06933.

Ripa, L. A. D.; Petros, Z. A.; Cioffi, A. G.; Piehl, D. W.; Courtney, J. M.; Burke, M. D.; Rienstra, C. M.
Solid-State NMR of Highly 13C-Enriched Cholesterol in Lipid Bilayers.
Methods 2018, 138–139, 47–53. https://doi.org/10.1016/j.ymeth.2018.01.008.

Grillo, A. S.; SantaMaria, A. M.; Kafina, M. D.; Cioffi, A. G.; etc.; Burke, M. D.
Restored Iron Transport by a Small Molecule Promotes Absorption and Hemoglobinization in Animals.
Science 2017, 356, 608–615. https://doi.org/10.1126/science.aah3862.

Endo, M. M.; Cioffi, A. G.; Burke, M. D.
Our Path to Less Toxic Amphotericins.
Synlett 2015, 27, 337. https://doi.org/10.1055/s-0035-1560800.

Davis, S. A.; Ripa, L. A. D.; Hu, L.; Cioffi, A. G.; Pogorelov, T. V.; Rienstra, C. M.; Burke, M. D.
C3-OH of Amphotericin B Plays an Important Role in Ion Conductance.
J. Am. Chem. Soc. 2015, 137, 15102–15104. https://doi.org/10.1021/jacs.5b05766.

Cioffi, A. G.; Hou, J.; Grillo, A. S.; Diaz, K. A.; Burke, M. D.
Restored Physiology in Protein-Deficient Yeast by a Small Molecule Channel.
J. Am. Chem. Soc. 2015, 137, 10096–10099. https://doi.org/10.1021/jacs.5b05765.

Anderson, T. M.; Clay, M. C.; Cioffi, A. G.; Diaz, K. A.; Hisao, G. S.; Tuttle, M. D.; etc.; Burke, M. D.
Amphotericin Forms an Extramembranous and Fungicidal Sterol Sponge.
Nat. Chem. Biol. 2014, 10, 400–406. https://doi.org/10.1038/nchembio.1496.

Wilcock, B. C.; Endo, M. M.; Uno, B. E.; Burke, M. D.
C2′-OH of Amphotericin B Plays an Important Role in Binding the Primary Sterol of Human Cells but Not Yeast Cells.
J. Am. Chem. Soc. 2013, 135, 8488–8491. https://doi.org/10.1021/ja403255s.

Gray, K. C.; Palacios, D. S.; Dailey, I.; Endo, M. M.; Uno, B. E.; Wilcock, B. C.; Burke, M. D.
Amphotericin Primarily Kills Yeast by Simply Binding Ergosterol.
Proc. Natl. Acad. Sci. U.S.A. 2012, 109, 2234–223. https://doi.org/10.1073/pnas.1117280109.

All Publications

Democratizing Machine Learning in Chemistry with Community-Engaged Test Sets.
Wu, J. L.; Friday, D. M.; Hwang, C.; Yi, C.; Torres-Flores, T. C.; Burke, M. D.; Diao, Y.; Schroeder, C. M.; Jackson, N. E.  
Digital Discovery 2026, 5, 304–309. 
https://doi.org/10.1039/D5DD00424A

Molecular Prosthetics for CFTR Designed for Anion Selectivity Outperform Amphotericin B in Cultured Cystic Fibrosis Airway Epithelia.
Marin-Toledo, J. P.; Greenan, D.; Celis, N.; Haske, L.; Lewandowska, A.; …
bioRxiv 2025, 2025.08.28.671923.
https://doi.org/10.1101/2025.08.28.671923.

Molecular Prosthetics and CFTR Modulators Additively Increase Secretory HCO₃⁻ Flux in Cystic Fibrosis Airway Epithelia.
Celis, N.; Miller, D. P.; Tarara, T. E.; Weers, J. G.; Thornell, I. M.; Welsh, M. J.; Burke, M. D.; …
ACS Chem. Biol. 2025.
https://doi.org/10.1021/acschembio.5c00473.

Illuminating the Interface of Blocc Chemistry and Data Science: An Introduction to K-Nearest Neighbor Analysis and K-Medoids Clustering.
Green, N. M.; Putnam, J. L. B.; Hammond, R. I.; Angello, N. H.; Planey, J.; Brandt, D.; Andino Martinez, J.; Hummel, T.; Gunasekera, B.; Switzky, R.; Desmond, S.; Burke, M. D.
J. Chem. Educ. 2025, 102 (12), 5273–5281.
https://doi.org/10.1021/acs.jchemed.5c00796.

Illuminating the Interface of Blocc Chemistry and Data Science: An Introduction to K-Nearest Neighbor Analysis and K-Medoids Clustering.
Green, N. M.; Putnam, J. L. B.; Hammond, R. I.; Angello, N. H.; Planey, J.; Brandt, D.; Andino Martinez, J.; Hummel, T.; Gunasekera, B.; Switzky, R.; Desmond, S.; Burke, M. D.
J. Chem. Educ. 2025, ASAP.
https://doi.org/10.1021/acs.jchemed.5c00796

mCLM: A Modular Chemical Language Model that Generates Functional and Makeable Molecules.
Edwards, C.; Han, C.; Lee, G.; Nguyen, T.; Jin, B.; Prasad, C. K.; Szymkuć, S.; …
arXiv 2025, arXiv:2505.12565.
https://doi.org/10.48550/arXiv.2505.12565.

Catalytic Allylation of Native Hexoses and Pentoses in Water with Indium.
Adak, T.; Menard, T.; Albritton, M.; Florit, F.; Burke, M. D.; Jensen, K. F.; …
Nature 2025, 640, 94–99.
https://doi.org/10.1038/s41586-025-08690-z.

Automated Iterative N–C and C–C Bond Formation.
Tyrikos-Ergas, T.; Agiakloglou, S.; LaPorte, A. J.; Wang, W.; Chan, C. K.; Wells, C. E.; …
Angew. Chem., Int. Ed. 2025, 64, e202509974.
https://doi.org/10.1002/anie.202509974.

Farm: Functional Group-Aware Representations for Small Molecules.
Nguyen, T.; Huang, K. H.; Liu, G.; Burke, M. D.; Diao, Y.; Ji, H.
arXiv 2024, arXiv:2410.02082.
https://doi.org/10.48550/arXiv.2410.02082.

Closed-Loop Transfer Enables Artificial Intelligence to Yield Chemical Knowledge.
Angello, N. H.; Friday, D. M.; Hwang, C.; Yi, S.; Cheng, A. H.; Torres-Flores, T. C.; …
Nature 2024, 633, 351–358.
https://doi.org/10.1038/s41586-024-07892-1.

Rapid Automated Iterative Small-Molecule Synthesis.
Wang, W.; Angello, N. H.; Blair, D. J.; Tyrikos-Ergas, T.; Krueger, W. H.; …
Nat. Synth. 2024, 3 (8), 1031–1038.
https://doi.org/10.1038/s44160-024-00601-w.

Delocalized, Asynchronous, Closed-Loop Discovery of Organic Laser Emitters.
Strieth-Kalthoff, F.; Hao, H.; Rathore, V.; Derasp, J.; Gaudin, T.; Angello, N. H.; …
Science 2024, 384 (6697), eadk9227.
https://doi.org/10.1126/science.adk9227.

Molecule Maker Lab Institute: Accelerating, Advancing, and Democratizing Molecular Innovation.
Martin D. Burke, Scott E. Denmark, Ying Diao, Jiawei Han, Rachel Switzky, and Huimin Zhao
AI Mag. 2024, 45 (1), 117–123.
https://doi.org/10.1002/aaai.12154.

Computational Prediction of Complex Cationic Rearrangement Outcomes.
Klucznik, T.; Syntrivanis, L.-D.; Baś, S.; Mikulak-Klucznik, B.; Moskal, M.; …
Nature 2024, 625, 508–515.
https://doi.org/10.1038/s41586-023-06854-3.

Minimizing Higher-Order Aggregation Maximizes Iron Mobilization by Small Molecules.
Blake, A. D.; Chao, J.; SantaMaria, A. M.; Snead, N. M.; Matje, D. M.; Green, K. J.; …
Nat. Chem. Biol. 2024, 20 (10), 1282–1293.
https://doi.org/10.1038/s41589-024-01596-3.

Reaction Miner: An Integrated System for Chemical Reaction Extraction from Textual Data.
Zhong, M.; Ouyang, S.; Jiao, Y.; Kargupta, P.; Luo, L.; Shen, Y.; Zhou, B.; Zhong, X.; …
EMNLP Proceedings 2023.
https://doi.org/10.18653/v1/2023.emnlp-demo.36.

Tuning Sterol Extraction Kinetics Yields a Renal-Sparing Polyene Antifungal.
Maji, A.; Soutar, C. P.; Zhang, J.; Lewandowska, A.; Uno, B. E.; Yan, S.; …
Nature 2023, 623 (7989), 1079–1085.
https://doi.org/10.1038/s41586-023-06710-4.

MIDA- and TIDA-Boronates Stabilize α-Radicals Through B–N Hyperconjugation.
LaPorte, A. J.; Feldner, J. E.; Spies, J. C.; Maher, T. J.; Burke, M. D.
Angew. Chem., Int. Ed. 2023, 135 (40), e202309566.
https://doi.org/10.1002/anie.202309566.

Amphotericin B Cystetic for Inhalation (CM001): A Randomized, Double-Blind, Placebo-Controlled, Single-Ascending-Dose Study in Healthy Volunteers.
Burke, M.; Welsh, M.; Weers, J.; Sellwood, C.; Reisner, C.
J. Cystic Fibrosis 2023, 22, S129.

Segmental Dynamics of Membranous Cholesterol Are Coupled.
Della Ripa, L. A.; Courtney, J. M.; Phinney, S. M.; Borcik, C. G.; Burke, M. D.; …
J. Am. Chem. Soc. 2023, 145 (28), 15043–15048.
https://doi.org/10.1021/jacs.3c01775.

SynerGPT: In-Context Learning for Personalized Drug Synergy Prediction and Drug Design.
Edwards, C.; Naik, A.; Khot, T.; Burke, M. D.; Ji, H.; Hope, T.
bioRxiv 2023, 2023.07.06.54775.
https://doi.org/10.1101/2023.07.06.547759.

Robust Model-Based Optimization for Challenging Fitness Landscapes.
Ghaffari, S.; Saleh, E.; Schwing, A. G.; Wang, Y.-X.; Burke, M. D.; Sinha, S.
arXiv 2023, arXiv:2305.13650.
https://doi.org/10.48550/arXiv.2305.13650.

A Materials Acceleration Platform for Organic Laser Discovery.
Wu, T. C.; Aguilar-Granda, A.; Hotta, K.; Yazdani, S. A.; Pollice, R.; Vestfrid, J.; …
Adv. Mater. 2023, 35 (6), 2207070.
https://doi.org/10.1002/adma.202207070.

Closed-Loop Optimization of General Reaction Conditions for Heteroaryl Suzuki–Miyaura Coupling.
Angello, N. H.; Rathore, V.; Beker, W.; Wołos, A.; Jira, E. R.; Roszak, R.; Wu, T. C.; Aspuru-Guzik, A.; Grzybowski, B. A.; Burke, M. D.; et al.
Science 2022, 378 (6618), 399–405.
https://doi.org/10.1126/science.adc8743. 

Automated Iterative Csp³–C Bond Formation.
Blair, D. J.; Chitti, S.; Trobe, M.; Kostyra, D. M.; Haley, H. M. S.; Hansen, R. L.; et al.; Burke, M. D.
Nature 2022, 604, 92–97.
https://doi.org/10.1038/s41586-022-04491-w. 

A Materials Acceleration Platform for Organic Laser Discovery.
Wu, T. C.; Aguilar-Granda, A.; Hotta, K.; Yazdani, S. A.; Pollice, R.; Vestfrid, J.; Hao, H.; Burke, M. D.; et al.
Adv. Mater. 2022, 34/35, 2207070.
https://doi.org/10.26434/chemrxiv-2022-9zm65. 

Digitizing Chemical Synthesis in 3D-Printed Reactionware.
Bubliauskas, A.; Blair, D. J.; Powell-Davies, H.; Kitson, P. J.; Burke, M. D.; Cronin, L.
Angew. Chem., Int. Ed. 2022, 134 (24), e202116108.
https://doi.org/10.1002/anie.202116108. 

Machine Learning May Sometimes Simply Capture Literature Popularity Trends: A Case Study of Heterocyclic Suzuki–Miyaura Coupling.
Beker, W.; Roszak, R.; Wołos, A.; Angello, N. H.; Rathore, V.; Burke, M. D.; Grzybowski, B. A.
J. Am. Chem. Soc. 2022, 144 (11), 4819–4827.
https://doi.org/10.1021/jacs.1c12005. 

Iterations from the Chemical Cosmos.
Loving, D. C.; Burke, M. D.
Nat. Synth. 2022, 1, 11–12.
https://doi.org/10.1038/s44160-021-00014-z. 

Mitigation of SARS-CoV-2 Transmission at a Large Public University.
Ranoa, D. R. E.; Holland, R. L.; Alnaji, F. G.; Green, K. J.; Wang, L.; et al.; Burke, M. D.
Nat. Commun. 2022, 13, 3207.
https://doi.org/10.1038/s41467-022-30833-3. 

Using Automated Synthesis to Understand the Role of Side Chains on Molecular Charge Transport.
Li, S.; Jira, E. R.; Angello, N. H.; Li, J.; Yu, H.; Moore, J. S.; Diao, Y.; Burke, M. D.; Schroeder, C. M.
Nat. Commun. 2022, 13, 2102.
https://doi.org/10.1038/s41467-022-29796-2. 

A Small Molecule Redistributes Iron in Ferroportin-Deficient Mice and Patient-Derived Primary Macrophages.
Ekaputri, S.; Choi, E.-K.; Sabelli, M.; Aring, L.; Green, K. J.; Chang, J. O.; Bao, K.; Burke, M. D.; Seo, Y.-A.
Proc. Natl. Acad. Sci. U.S.A. 2022, 119, e2121400119.
https://doi.org/10.1073/pnas.2121400119. 

Targeting Fungal Membrane Homeostasis with Imidazopyrazoindoles Impairs Azole Resistance and Biofilm Formation.
Revie, N. M.; Iyer, K. R.; Maxson, M. E.; Zhang, J.; Yan, S.; Fernandes, C. M.; Burke, M. D.; et al.
Nat. Commun. 2022, 13, 3634.
https://doi.org/10.1038/s41467-022-31308-1. 

Preparation of MIDA anhydride and Reaction with Boronic Acids.
Kelly, A. M.; Chen, P. J.; Klubnick, J.; Blair, D. J.; Burke, M. D.
Org. Synth. 2022, 99, 92.
https://doi.org/10.15227/orgsyn.099.0092. 

Fungicidal Amphotericin B Sponges Are Assemblies of Staggered Asymmetric Homodimers Encasing Large Void Volumes.
Lewandowska, A.; Soutar, C. P.; Greenwood, A. I.; Nimerovsky, E.; De Lio, A. M.; Burke, M. D.; Rienstra, C. M.; et al.
Nat. Struct. Mol. Biol. 2021, 28 (12), 972–981.
https://doi.org/10.1038/s41594-021-00685-4. 

Chemical-Reaction-Aware Molecule Representation Learning.
Wang, H.; Li, W.; Jin, X.; Cho, K.; Ji, H.; Han, J.; Burke, M. D.
arXiv 2021, arXiv:2109.09888.
https://doi.org/10.48550/arXiv.2109.09888. 

Transition between Nonresonant and Resonant Charge Transport in Molecular Junctions.
Li, S.; Yu, H.; Li, J.; Angello, N. H.; Jira, E. R.; Li, B.; Burke, M. D.; Moore, J. S.
Nano Lett. 2021, 21 (19), 8340–8347.
https://doi.org/10.1021/acs.nanolett.1c02915. 

Well-Tolerated Amphotericin B Derivatives That Effectively Treat Visceral Leishmaniasis.
Morelle, C.; Mukherjee, A.; Zhang, J.; Fani, F.; Khandelwal, A.; Gingras, H.; Burke, M. D.; Ouellette, M.
ACS Infect. Dis. 2021, 7 (8), 2472–2482.
https://doi.org/10.1021/acsinfecdis.1c00245. 

Sterol Sponge Mechanism Is Conserved for Glycosylated Polyene Macrolides.
Guo, X.; Zhang, J.; Li, X.; Xiao, E.; Lange, J. D.; Rienstra, C. M.; Burke, M. D.; Mitchell, D. A.
ACS Cent. Sci. 2021, 7 (5), 781–791.
https://doi.org/10.1021/acscentsci.1c00148. 

Modular Synthesis Enables Molecular Ju-Jitsu in the Fight Against Antibiotic Resistance.
Blair, D. J.; Burke, M. D.
Nature 2020, 586, 32–33.
https://doi.org/10.1038/d41586-020-02565-1. 

A Mild Method for Making MIDA Boronates.
Kelly, A. M.; Chen, P. J.; Klubnick, J.; Blair, D. J.; Burke, M. D.
Org. Lett. 2020, 22 (24), 9408–9414.
https://doi.org/10.1021/acs.orglett.0c02449.

Amphotericin B Induces Epithelial Voltage Responses in People with Cystic Fibrosis.
Chorghade, R. S.; Kim, B. R.; Launspach, J. L.; Karp, P. H.; Welsh, M. J.; Burke, M. D.
J. Cyst. Fibros. 2020, 19 (5), 781–791.
https://doi.org/10.1016/j.jcf.2020.11.018.

Saliva-Based Molecular Testing for SARS-CoV-2 That Bypasses RNA Extraction.
Ranoa, D. R. E.; Holland, R. L.; Alnaji, F. G.; Green, K. J.; Wang, L.; Brooke, C. B.; Burke, M. D.; et al.
bioRxiv 2020, 2020.06.18.159434.
https://doi.org/10.1101/2020.06.18.159434. 

Small Molecule Channels Harness Membrane Potential to Concentrate Potassium in trk1Δtrk2Δ Yeast.
Hou, J.; Daniels, P. N.; Burke, M. D.
ACS Chem. Biol. 2020, 15 (6), 1575–1580.
https://doi.org/10.1021/acschembio.0c00180. 

Modular Syntheses of Phenanthroindolizidine Natural Products.
Jo, Y.-I.; Burke, M. D.; Cheon, C.-H.
Org. Lett. 2019, 21 (11), 4201–4204.
https://doi.org/10.1021/acs.orglett.9b01397. 

Axial Shielding of Pd(II) Complexes Enables Perfect Stereoretention in Suzuki–Miyaura Cross-Coupling of Csp³ Boronic Acids.
Lehmann, J. W.; Crouch, I. T.; Blair, D. J.; Trobe, M.; Wang, P.; Li, J.; Burke, M. D.
Nat. Commun. 2019, 10, 1263.
https://doi.org/10.1038/s41467-019-09249-z. 

Small-Molecule Ion Channels Increase Host Defences in Cystic Fibrosis Airway Epithelia.
Muraglia, K. A.; Chorghade, R. S.; Kim, B. R.; Tang, X. X.; Shah, V. S.; Grillo, A. S.; Daniels, P. N.; Cioffi, A. G.; Karp, P. H.; Zhu, L.; Welsh, M. J.; Burke, M. D.
Nature 2019, 567, 405–408.
https://doi.org/10.1038/s41586-019-1018-5. 

FAM210B Is an Erythropoietin Target and Regulates Erythroid Heme Synthesis by Controlling Mitochondrial Iron Import and Ferrochelatase Activity.
Yien, Y. Y.; Shi, J.; Chen, C.; Cheung, J. T. M.; Grillo, A. S.; Shrestha, R.; Li, L.; Zhang, X.; et al.; Burke, M. D.
J. Biol. Chem. 2019, 293 (51), 19797–19811.
https://doi.org/10.1074/jbc.RA118.002742.

Stereoretentive Cross-Coupling of Boronic Acids.
Burke, M. D.; Crouch, I.; Lehmann, J.; Palazzolo, A.; Simons, C.; et al.
U.S. Patent 10,370,393, 2019.

Peridinin Is an Exceptionally Potent and Membrane-Embedded Inhibitor of Bilayer Lipid Peroxidation.
Haley, H. M. S.; Hill, A. G.; Greenwood, A. I.; Woerly, E. M.; Rienstra, C. M.; Burke, M. D.
J. Am. Chem. Soc. 2018, 140 (45), 15227–15240.
https://doi.org/10.1021/jacs.8b06933. 

The Molecular Industrial Revolution: Automated Synthesis of Small Molecules.
Trobe, M.; Burke, M. D.
Angew. Chem., Int. Ed. 2018, 57, 4192–4214.
https://doi.org/10.1002/anie.201710482. 

Towards the Generalized Iterative Synthesis of Small Molecules.
Lehmann, J. W.; Blair, D. J.; Burke, M. D.
Nat. Rev. Chem. 2018, 2, 0115.
https://doi.org/10.1038/s41570-018-0115. 

Solid-State NMR of Highly 13C-Enriched Cholesterol in Lipid Bilayers.
Della Ripa, L. A.; Petros, Z. A.; Cioffi, A. G.; Piehl, D. W.; Courtney, J. M.; Burke, M. D.; Rienstra, C. M.
Methods 2018, 138–139, 47–53.
https://doi.org/10.1016/j.ymeth.2018.01.008. 

Cross-Coupling of Unactivated Secondary Boronic Acids.
Burke, M. D.; Wang, P.; Crouch, I.
U.S. Patent 10,072,028, 2018.

The Natural Productome.
Palazzolo, A. M. E.; Simons, C. L. W.; Burke, M. D.
Proc. Natl. Acad. Sci. U.S.A. 2017, 114 (22), 5564–5566.
https://doi.org/10.1073/pnas.1706266114. 

Restored Iron Transport by a Small Molecule Promotes Absorption and Hemoglobinization in Animals.
Grillo, A. S.; SantaMaria, A. M.; Kafina, M. D.; Cioffi, A. G.; Huston, N. C.; et al.; Burke, M. D.
Science 2017, 356, 608–615.
https://doi.org/10.1126/science.aah3862. 

MIDA Boronates Are Hydrolysed Fast and Slow by Two Different Mechanisms.
Gonzalez, J. A.; Ogba, O. M.; Morehouse, G. F.; Rosson, N.; Houk, K. N.; Leach, A. G.; Burke, M. D.; Lloyd-Jones, G. C.
Nat. Chem. 2016, 8, 1067–1075.
https://doi.org/10.1038/nchem.2571.

Our Path to Less Toxic Amphotericins.
Endo, M. M.; Cioffi, A. G.; Burke, M. D.
Synlett 2016, 27 (3), 337–354.
https://doi.org/10.1055/s-0035-1560800. 

C3-OH of Amphotericin B Plays an Important Role in Ion Conductance.
Davis, S. A.; Della Ripa, L. A.; Hu, L.; Cioffi, A. G.; Pogorelov, T. V.; Rienstra, C. M.; Burke, M. D.
J. Am. Chem. Soc. 2015, 137 (48), 15102–15104.
https://doi.org/10.1021/jacs.5b05766. 

Restored Physiology in Protein-Deficient Yeast by a Small Molecule Channel.
Cioffi, A. G.; Hou, J.; Grillo, A. S.; Diaz, K. A.; Burke, M. D.
J. Am. Chem. Soc. 2015, 137 (32), 10096–10099.
https://doi.org/10.1021/jacs.5b05765. 

Nontoxic Antimicrobials That Evade Drug Resistance.
Davis, S. A.; Vincent, B. M.; Endo, M. M.; Whitesell, L.; Marchillo, K.; Andes, D. R.; Lindquist, S.; Burke, M. D.
Nat. Chem. Biol. 2015, 11, 481–487.
https://doi.org/10.1038/nchembio.1821. 

Synthesis of Many Different Types of Organic Small Molecules Using One Automated Process.
Li, J.; Ballmer, S. G.; Gillis, E. P.; Fujii, S.; Schmidt, M. J.; Palazzolo, A. M. E.; Lehmann, J. W.; Morehouse, G. F.; Burke, M. D.
Science 2015, 347, 1221–1226.
https://doi.org/10.1126/science.aaa5414. 

From Synthesis to Function via Iterative Assembly of N-Methyliminodiacetic Acid Boronate Building Blocks.
Li, J.; Grillo, A. S.; Burke, M. D.
Acc. Chem. Res. 2015, 48 (8), 2297–2307.
https://doi.org/10.1021/acs.accounts.5b00128. 

Synthesis of Most Polyene Natural Product Motifs Using Just Twelve Building Blocks and One Coupling Reaction.
Woerly, E. M.; Roy, J.; Burke, M. D.
Nat. Chem. 2014, 6, 484–491.
https://doi.org/10.1038/nchem.1947. 

Amphotericin Forms an Extramembranous and Fungicidal Sterol Sponge.
Anderson, T. M.; Clay, M. C.; Cioffi, A. G.; Diaz, K. A.; Hisao, G.; Tuttle, M. D.; Nieuwkoop, A. J.; Comellas, G.; Maryum, N.; Wang, S.; Uno, B. E.; Wildeman, E. L.; Gonen, T.; Rienstra, C. M.; Burke, M. D.
Nat. Chem. Biol. 2014, 10, 400–406.
https://doi.org/10.1038/nchembio.1496. 

(1-Bromovinyl)-MIDA Boronate: A Readily Accessible and Highly Versatile Building Block for Small-Molecule Synthesis.
Woerly, E. M.; Miller, J. E.; Burke, M. D.
Tetrahedron 2013, 69 (36), 7732–7740.
https://doi.org/10.1016/j.tet.2013.05.050. 

C2′-OH of Amphotericin B Plays an Important Role in Binding the Primary Sterol of Human Cells but Not Yeast Cells.
Wilcock, B. C.; Endo, M. M.; Uno, B. E.; Burke, M. D.
J. Am. Chem. Soc. 2013, 135 (23), 8488–8491.
https://doi.org/10.1021/ja403255s. 

Electronic Tuning of Site-Selectivity.
Wilcock, B. C.; Uno, B. E.; Bromann, G. L.; Clark, M. J.; Anderson, T. M.; Burke, M. D.
Nat. Chem. 2012, 4, 996–1003.
https://doi.org/10.1038/nchem.1495. 

Amphotericin Primarily Kills Yeast by Simply Binding Ergosterol.
Gray, K. C.; Palacios, D. S.; Dailey, I.; Endo, M. M.; Uno, B. E.; Wilcock, B. C.; Burke, M. D.
Proc. Natl. Acad. Sci. U.S.A. 2012, 109 (7), 2234–2239.
https://doi.org/10.1073/pnas.1117280109. 

A General Solution for the 2-Pyridyl Problem.
Dick, G. R.; Woerly, E. M.; Burke, M. D.
Angew. Chem., Int. Ed. 2012, 51, 2667–2672.
https://doi.org/10.1002/anie.201108608. 

Pinene-Derived Iminodiacetic Acid (PIDA): A Powerful Ligand for Stereoselective Synthesis and Iterative Cross-Coupling of C(sp³) Boronate Building Blocks.
Li, J.; Burke, M. D.
J. Am. Chem. Soc. 2011, 133 (35), 13774–13777.
https://doi.org/10.1021/ja205912y. 

Total Synthesis of Synechoxanthin through Iterative Cross-Coupling.
Fujii, S.; Chang, S. Y.; Burke, M. D.
Angew. Chem., Int. Ed. 2011, 50, 7862–7864.
https://doi.org/10.1002/anie.201102688. 

Synthesis-Enabled Functional Group Deletions Reveal Key Underpinnings of Amphotericin B Ion Channel and Antifungal Activities.
Palacios, D. S.; Dailey, I.; Siebert, D. M.; Wilcock, B. C.; Burke, M. D.
Proc. Natl. Acad. Sci. U.S.A. 2011, 108, 6733–6738.
https://doi.org/10.1073/pnas.1015023108. 

(Z)-(2-Bromovinyl)-MIDA Boronate: A Readily Accessible and Highly Versatile Building Block for Small Molecule Synthesis.
Woerly, E. M.; Struble, J. R.; Palyam, N.; O’Hara, S. P.; Burke, M. D.
Tetrahedron 2011, 67, 4333–4343.
https://doi.org/10.1016/j.tet.2011.04.021. 

A Simple and General Platform for Generating Stereochemically Complex Polyene Frameworks by Iterative Cross-Coupling.
Lee, S. J.; Anderson, T. M.; Burke, M. D.
Angew. Chem., Int. Ed. 2010, 49, 8860–8863.
https://doi.org/10.1002/anie.201004911.

Stereoretentive Suzuki–Miyaura Coupling of Haloallenes Enables Fully Stereocontrolled Access to (–)-Peridinin.
Woerly, E. M.; Cherney, A. H.; Davis, E. K.; Burke, M. D.
J. Am. Chem. Soc. 2010, 132 (20), 6941–6943.
https://doi.org/10.1021/ja102721p. 

A General Method for Synthesis of 2-Heterocyclic N-Methyliminodiacetic Acid Boronates.
Dick, G. R.; Knapp, D. M.; Gillis, E. P.; Burke, M. D.
Org. Lett. 2010, 12 (10), 2314–2317.
https://doi.org/10.1021/ol100671v. 

N-(Carboxymethyl)-N-Methylglycine.
Dailey, I.; Burke, M. D.
Encyclopedia of Reagents for Organic Synthesis 2010.
https://doi.org/10.1002/047084289X.rn01228. 

Ethynyl MIDA Boronate: A Readily Accessible and Highly Versatile Building Block for Small-Molecule Synthesis.
Dick, G. R.; Knapp, D. M.; Gillis, E. P.; Burke, M. D.
Tetrahedron 2010, 66, 4710–4718.
https://doi.org/10.1016/j.tet.2010.04.020. 

A General Solution for Unstable Boronic Acids: Slow-Release Cross-Coupling from Air-Stable MIDA Boronates.
Knapp, D. M.; Gillis, E. P.; Burke, M. D.
J. Am. Chem. Soc. 2009, 131 (20), 6961–6963.
https://doi.org/10.1021/ja901416p. 

Vinyl MIDA Boronate: A Readily Accessible and Highly Versatile Building Block for Small Molecule Synthesis.
Uno, B. E.; Gillis, E. P.; Burke, M. D.
Tetrahedron 2009, 65, 3130–3138.
https://doi.org/10.1016/j.tet.2008.11.010.

Flexible Tetracycline Synthesis Yields Promising Antibiotics.
Burke, M. D.
Nat. Chem. Biol. 2009, 5, 77–79.
https://doi.org/10.1038/nchembio0209-77. 

B-Protected Haloboronic Acids for Iterative Cross-Coupling.
Ballmer, S. G.; Gillis, E. P.; Burke, M. D.; Morton, D.; Davies, H. M. L.
Org. Synth. 2009, 86, 344–359.
https://doi.org/10.15227/orgsyn.086.0344. 

Iterative Cross-Coupling with MIDA Boronates: Towards a General Platform for Small-Molecule Synthesis.
Gillis, E. P.; Burke, M. D.
Aldrichimica Acta 2009, 42 (1), 17–27.

Multistep Synthesis of Complex Boronic Acids from Simple MIDA Boronates.
Gillis, E. P.; Burke, M. D.
J. Am. Chem. Soc. 2008, 130 (43), 14084–14085.
https://doi.org/10.1021/ja8063759. 

Simple, Efficient, and Modular Syntheses of Polyene Natural Products via Iterative Cross-Coupling.
Lee, S. J.; Gray, K. C.; Paek, J. S.; Burke, M. D.
J. Am. Chem. Soc. 2008, 130 (2), 466–468.
https://doi.org/10.1021/ja078129x. 

A Post-PKS Oxidation of the Amphotericin B Skeleton Predicted to Be Critical for Channel Formation Is Not Required for Potent Antifungal Activity.
Palacios, D. S.; Anderson, T. M.; Burke, M. D.
J. Am. Chem. Soc. 2007, 129 (45), 13804–13805.
https://doi.org/10.1021/ja075739o. 

A Simple and Modular Strategy for Small Molecule Synthesis: Iterative Suzuki–Miyaura Coupling of B-Protected Haloboronic Acid Building Blocks.
Gillis, E. P.; Burke, M. D.
J. Am. Chem. Soc. 2007, 129 (21), 6716–6717.
https://doi.org/10.1021/ja0716204. 

Molecular Prosthetics: Replicating the Functions of the Molecules of Life.
Burke, M. D.
ACS Enhancing Chemistry Conference, University of Illinois, Urbana, IL, March 17, 2006.