The Burke group aims to advance the frontiers of pharmacology towards molecular prosthetics, i.e., functional small molecules that serve as substitutes for missing or dysfunctional proteins that underlie currently incurable human diseases.
The Burke research group is pioneering the development of “molecular prosthetics”—small molecules that mimic the functions of deficient proteins that underlie a wide range of human diseases. The group has also created an automatable lego-like platform for synthesis that is broadly enabling and expanding access to the molecule-making process. The Burke group has harnessed this platform to advance molecular prosthetics for treating cystic fibrosis into clinical trials and to enable preclinical testing of molecular prosthetics for anemia and a new class of nontoxic fungicidal agents.
Marty Burke also helped launch the Carle Illinois College of Medicine as the inaugural associate dean for research, created the molecule making machine and leads the effort to develop the Molecule Maker Lab. Marty utilizes his on-demand molecule-making machine to develop molecular prosthetics, small molecules that replace missing proteins and restore function in cells. These prosthetics may treat diseases such as anemias, cystic fibrosis or certain types of heart disease.
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