Author: lilyho3
Marty Burke completed a PhD in Chemistry at Harvard and a M.D. in the Health Sciences and Technology Program at Harvard Medical School and MIT. He is now the May and Ving Lee Professor for Chemical Innovation at UIUC, and helped launch the Carle Illinois College of Medicine by serving as the inaugural Associate Dean for Research. Burke is a pioneer in the development of molecular prosthetics, automated small molecule synthesis, and renal-sparing polyene antifungals. His lab first showed that small molecules can replace deficient proteins and thereby restore physiology in animals, and in people, thus operating like prostheses on the molecular scale. He identified a molecular prosthetic for cystic fibrosis that achieved proof-of-concept in an investigator-initiated clinical trial, and one for anemias (advanced pre-clinical development). Burke further showed how the robustness of living systems interfaces with imperfect small molecule mimics to restore physiology. Burke’s lab also developed an automated lego-like platform for small molecule synthesis based on MIDA boronates that is increasingly general. His MIDA boronate chemistry has now been used by >250 academic and industrial labs worldwide to make a wide range of different natural products, pharmaceuticals, materials, and many other types of small molecules (>750 publications, >200 patent applications), and >270 of his MIDA boronates are commercially available. Burke’s group leveraged this platform in collaboration with Chad Rienstra to discover that the clinically vital but also highly toxic fungicidal natural product amphotericin B primarily kills cells by forming an extramembranous sterol sponge, a mechanism that had evaded the scientific community for more than half a century. This enabled Burke to rationally separate the ion channel-forming activity of this natural product to develop molecular prosthetics for cystic fibrosis, and to design a renal-sparing polyene antifungal (advanced preclinical development for life-threatening invasive fungal infections). Based on these advances, Burke (co)-founded four biotechnology companies [REVOLUTION Medicines (Nasdaq: RVMD), cystetic Medicines, Ambys Medicines, and Sfunga Therapeutics], which collectively have one drug candidate in Ph 2, and three more on track to begin clinical trials in 2023. And he co-founded the Molecule Maker Lab Institute that is broadly expanding access to automated small molecule synthesis. Burke also lead the SHIELD: Test, Target, and Tell program at UIUC that created and scalably deployed an FDA Emergency Use Authorized rapid saliva test for SARS-CoV-2, and strategically integrated it with state-of-the-art computational modeling and a custom-built app, to mitigate the spread of COVID-19 at UIUC. As a leader in COVID-19 testing, he also worked with NASEM Societal Experts Action Network, NASEM Naval Studies Board, U.S. Marine Corps, Council on Foreign Relations, American Public Health Association, Rockefeller Foundation, Office of the U.S. Assistant Secretary for Health, and the White House COVID-19 Response Team. Burke also helped SHIELD Illinois and SHIELD T3 expand this testing platform to >1700 K-12 schools, colleges, universities, companies, and organizations throughout the U.S. and other countries, including New Zealand, Philippines, and Indonesia. Worldwide, greater than 10 million COVID-19 tests have been run to date.
Burke’s contributions have been recognized with many honors and awards, including newly‑elected member of the National Academy of Medicine (NAM), Fellow, American Association for the Advancement of Science, the Presidential Medallion (University of Illinois), Membership in the American Society for Clinical Investigation, Mukaiyama Award (The Society of Synthetic Organic Chemistry, Japan), Nobel Laureate Signature Award for Graduate Education in Chemistry (American Chemical Society), Hirata Gold Medal (Japan), Theme-IUPAC Prize in Synthetic Organic Chemistry, Elias J. Corey Award for Outstanding Original Contribution in Organic Synthesis by a Young Investigator (American Chemical Society), Kavli Foundation Emerging Leader in Chemistry Award (American Chemical Society), Arthur C. Cope Scholar Award (American Chemical Society), one of the world’s 35 Top Innovators Under 35 (Technology Review Magazine ), and has been repeatedly recognized as a Teacher Ranked as Excellent by the UIUC Center for Teaching Excellence.
2022 Member, National Academy of Medicine (NAM) 2022 Fellow, American Association for the Advancement of Science
2021 Presidential Medallion, University of Illinois
2021 Johns Hopkins University Distinguished Alumnus Award
2021 LAS Impact Award, UIUC
2021 Member, American Society for Clinical Investigation
2020 Mukaiyama Award, The Society of Synthetic Organic Chemistry, Japan
2019 iCON Award, iBIO
2017 University Scholars Award, UIUC
2017 Nobel Laureate Signature Award in Graduate Education in Chemistry, ACS
2016 Maximizing Investigator’s Research Award, National Institutes of Health
2016 Bristol-Myers Squibb Lectureship, Harvard University
2016 Aldrich Lectureship, McGill University and University of Montreal, Canada
2016 Burkett Lectureship, Depauw University
2015 University of Bristol Chemical Synthesis CDT-Syngenta Award, UK
2014 Thieme-International Union of Pure and Applied Chemistry Prize in Synthetic O/C
2014 American Asthma Foundation Scholars Award
2014 Hirata Gold Medal, Japan
2014 International Organic Chemistry Foundation Lectureship Award, Japan
2013 Kavli Foundation Emerging Leader in Chemistry Award, American Chemical Society
2013 Elias J. Corey Award for Outstanding Original Contribution in Organic Synthesis by a
Young Investigator, American Chemical Society
2013 University of Illinois Innovation Discovery Award
2012 Novartis Chemistry Lectureships
2011 Arthur C. Cope Scholar Award, American Chemical Society
2011 Teacher Ranked as Excellent, UIUC Center for Teaching Excellence
2010 Bristol-Myers Squibb Lectureship at Harvard University
2010 Frontiers in Chemistry Lectureship at The Scripps Research Institute
2010 Novartis Lectureship at The University of California Berkeley
2009 Howard Hughes Medical Institute Early Career Scientist
2009 Alfred P. Sloan Foundation Research Fellowship
2009 Bristol-Myers Squibb Unrestricted Grant in Synthetic Organic Chemistry Award
2009 Eli Lilly Grantee Award
2009 AstraZeneca Excellence in Chemistry Award
2009 Amgen Young Investigator Award
2009 Bristol-Myers Squibb Lectureship at Princeton University
2009 Thieme Chemistry Journals Award
2008 Teacher Ranked as Excellent, UIUC Center for Teaching Excellence
2008 Arnold and Mabel Beckman Foundation Young Investigator Award
2008 “World’s 35 Top Innovators Under 35” Technology Review Magazine
2008 National Science Foundation CAREER Award
2008 “Scientist to Watch” The Scientist Magazine
2007 Teacher Ranked as Outstanding, UIUC Center for Teaching Excellence
2006 Teacher Ranked as Excellent, UIUC Center for Teaching Excellence
2005 ACS Petroleum Research Foundation Type G Award
2005 Camille and Henry Dreyfus New Faculty Award
2005 Henry Asbury Christian Award, Harvard Medical School
2003 National Institutes of Health Medical Scientist Training Program Fellowship
2000 Howard Hughes Medical Institute Predoctoral Fellowship
1998 Hunterian Research Award – Johns Hopkins Department of Neurosurgery
1997 Phi Beta Kappa – Junior Year, Johns Hopkins University
1997 Howard Hughes Undergraduate Research Fellowship – Johns Hopkins University
1997 Provost’s Undergraduate Research Award – Johns Hopkins University
1994-1998 Dean’s List – Johns Hopkins University
1994-1998 Beneficial Hodson Scholar – Johns Hopkins University
1994-1998 Maryland Distinguished Scholar
A complete list of Marty’s publications and awards can be found on his current CV.
For a biographical sketch of Marty as a “Scientist to Watch” in The Scientist magazine click here.
To view a free Chem. and Eng. News “Webinar” in which Marty describes the group’s research see: http://pubs.acs.org/cen/webinar/webinar-sigma.html
For a discussion with Marty on being a chemist and the prospect of molecular prosthetics, see: http://publications.nigms.nih.gov/chemhealth/chemist_burke.html
195. January 2020 Organic Seminar, University of Colorado Boulder
196. February 2020 Gregory Fleming James Cystic Fibrosis Research Center Seminar Series, The University of Alabama at Birmingham
197. March 2020 Department of Pharmacology and Molecular Sciences Seminar, Johns Hopkins University
198. April 2020 Royal Dutch Chemical Society (KNCV) International Symposium on Organic
Chemistry, Wageningen, The Netherlands (postponed)
199. June 2020 Metals in Medicine Gordon Research Conference, Proctor Academy in Andover, NH United States (postponed)
200. August 2020 Office of the Assistant Secretary for Health, COVID-19 Surveillance Testing
Educational Webinar Speaker
201. September 2020 37th Mukaiyama Award in Synthetic Organic Chemistry Virtual Symposium, Hiroshima, Japan
202. September 2020 American Public Health Association and the National Academy of Medicine, Controlling COVID-19: Surveillance, Testing and Contact Panel
203. September 2020 Council on Foreign Relations (CFR), Higher Education Webinar: Targeting, Testing, and Mitigating the Spread of COVID-19
204. October 2020 Department of Chemistry & Biochemistry Virtual Seminar, Baylor University
205. October 2020 Princeton ACS Meeting, Virtual Lecture, Piscataway, NJ
206. October 2020 42nd Princeton ACS Fall Organic Virtual Symposium, Princeton
207. October 2020 The National Academies of Sciences, Engineering, & Medicine Societal
Experts Action Network: COVID-19 Testing Strategies for Colleges & Universities
208. October 2020 Rockefeller Foundation Cross-Cities Group
209. October 2020 National Academy of Science Engineering & Medicine Naval Studies Board (NSB) -U.S. Marine Corps (USMC) Meeting of Experts
210. October 2020 Rockefeller Foundation Convening
211. December 2020 Abbott Media Education Webinar: The State of COVID-19 Testing
212. December 2020 University of New Hampshire: Keeping Campus Safe
213. March 2021 JCESR Artificial Intelligence (AI) for Energy Storage Workshop
214. March 2021 BU PDC Symposium
215. April 2021 ACS Spring Meeting: Imagine a world where everyone can make molecules
216. August 2021 ACS Presidential Symposium
217. October 2021 University of Mumbai Virtual Lecture
218. December 2021 University of Illinois President’s Advisory Council
Professor – Carle Illinois College of Medicine Professor – Beckman Institute
Affiliate – Biochemistry
Affiliate – Carl R. Woese Institute for Genomic Biology